04-123
Anti-TAL-1 Antibody, clone BTL73
clone BTL73, Upstate®, from mouse
Sinonimo/i:
SCL, T-cell acute lymphocytic leukemia 1, TCL5, TAL-1, Stem cell protein
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Origine biologica
mouse
Livello qualitativo
Forma dell’anticorpo
purified antibody
Tipo di anticorpo
primary antibodies
Clone
BTL73, monoclonal
Purificato mediante
affinity chromatography
Reattività contro le specie
human
Produttore/marchio commerciale
Upstate®
tecniche
immunohistochemistry: suitable
western blot: suitable
Isotipo
IgG1κ
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
Informazioni sul gene
human ... TAL1(6886)
Descrizione generale
TAL-1, also known as SCL (stem cell leukemia), is a serine phosphoprotein and basic-helix-loop-helix transcription factor. TAL-1 is implicated in the genesis of hemopoietic malignancies and is a positive regulator of erythroid differentiation. A nonrandom, site-specific TAL-1 chromosomal translocation is commonly associated with oncogenic transformation in many T-cell acute lymphoblastic leukemias. TAL-1 binds to the LIM domain containing protein Rhombotin 2 (RBTN2), where it forms a complex with GATA1 or GATA 2 that is essential for erythropoiesis.
Specificità
This antibody detects two predominant protein products of the SCL/TAL1 gene in T cell acute lymphoblastic leukemia (T-ALL): a full length PP42-TAL1 (42/44 kDa) and a truncated form PP24-TAL1 (24/26 kDa).
Immunogeno
Epitope: C-Terminus
Recombinant GST-TAL1 (K Pulford, et al., 1995, Blood, 85: 675 - 684)
Applicazioni
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
Use Anti-TAL-1 Antibody, clone BTL73 (Mouse Monoclonal Antibody) validated in WB, IHC to detect TAL-1 also known as SCL, T-cell acute lymphocytic leukemia 1, TCL5, TAL-1, Stem cell protein.
Western Blot Analysis: 2 μg/mL of this lot detected a strong 44 kDa of PP42-TAL1 in Jurkat cell lysate, and also very faint PP24-TAL. Optimal working dilutions must be determined by the end user.
Qualità
Routinely evaluated by western blot on Jurkat cell lysate.
Descrizione del bersaglio
44 kDa
Stato fisico
Protein G Purified
Purified mouse monoclonal IgG1k in buffer containing PBS and 0.05% sodium azide.
Stoccaggio e stabilità
Stable for 1 year at 2-8°C from date of receipt. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Risultati analitici
Control
Jurkat cell lysate
Jurkat cell lysate
Altre note
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Note legali
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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