D-115

Doxepin-D₃ (cis/trans) hydrochloride solution

1.0 mg/mL in methanol (as free base), certified reference material, Cerilliant^®

• Formula empirica (notazione di Hill): C₁₉H₁₈D₃NO · HCl
• Numero CAS: 347840-07-7
• Peso molecolare: 318.86
• Numero MDL: MFCD01074151
• Codice UNSPSC: 41116107
• ID PubChem: 329798673
• NACRES: NA.24

Proprietà

• Grado: certified reference material
• Livello qualitativo: 300
• Forma fisica: liquid
• Caratteristiche: Snap-N-Spike^®/Snap-N-Shoot^®
• Confezionamento: ampule of 1 mL
• Produttore/marchio commerciale: Cerilliant^®
• Concentrazione: 1.0 mg/mL in methanol (as free base)
• tecniche: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• applicazioni: clinical testing
• Formato: single component solution
• Temperatura di conservazione: −20°C
• Stringa SMILE: CN(C([2H])([2H])[2H])CC/C=C1C2=C(C=CC=C2)COC3=C/1C=CC=C3.[H]Cl
• InChI: 1S/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11-;/i1D3;; MHNSPTUQQIYJOT-JSMHCMNYSA-N

Descrizione

Descrizione generale

Doxepin is a tricyclic antidepressant used for the treatment of sleep maintenance. This internal standard is applicable for doxepin testing or isotope dilution methods by GC/MS or LC/MS for clinical toxicology, urine drug testing, or forensic analysis applications.

Applicazioni

• High-throughput protein precipitation method for doxepin analysis: A study presented a protein precipitation method using a 96-well plate to determine doxepin and nordoxepin levels in human plasma, employing LC-MS/MS, highlighting the utility of stable isotope-labeled doxepin for quantitative analysis in clinical settings (Margaryan et al., 2020).


• LC-MS-MS analysis of neuroleptics including doxepin: Research detailed the use of LC-MS-MS for analyzing neuroleptics like doxepin in hair samples from psychiatric patients, demonstrating the method′s effectiveness for long-term medication monitoring (Weinmann et al., 2002).


• Detection of doxepin in hair following therapy: A study investigated the detection of doxepin and its major metabolite in hair, providing a methodological foundation for forensic and clinical assessments of drug therapy adherence using hair samples (Negrusz et al., 1998).

Note legali

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS02,GHS06,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H225,H301 + H311 + H331,H370
• Consigli di prudenza: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Classi di pericolo: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Organi bersaglio: Eyes
• Codice della classe di stoccaggio: 3 - Flammable liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): 49.5 °F - closed cup
• Punto d’infiammabilità (°C): 9.7 °C - closed cup