D-049
N-Desmethylclobazam solution
100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
About This Item
Formula empirica (notazione di Hill):
C15H11ClN2O2
Numero CAS:
Peso molecolare:
286.71
Numero CE:
Numero MDL:
Codice UNSPSC:
41116107
ID PubChem:
NACRES:
NA.24
Prodotti consigliati
Grado
certified reference material
Livello qualitativo
Stato
liquid
Caratteristiche
Snap-N-Spike®/Snap-N-Shoot®
Confezionamento
ampule of 1 mL
Produttore/marchio commerciale
Cerilliant®
Concentrazione
100 μg/mL in acetonitrile
tecniche
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
applicazioni
clinical testing
Formato
single component solution
Temperatura di conservazione
−20°C
Stringa SMILE
O=C(C1)N(C2=CC=CC=C2)C3=C(C=CC(Cl)=C3)NC1=O
InChI
1S/C15H11ClN2O2/c16-10-6-7-12-13(8-10)18(11-4-2-1-3-5-11)15(20)9-14(19)17-12/h1-8H,9H2,(H,17,19)
RRTVVRIFVKKTJK-UHFFFAOYSA-N
Descrizione generale
A Certified Solution Standard for use in LC or GC applications from forensic and forensic toxicology analysis to urine drug testing. N-Desmethylclobazam, found in urine, serum, and plasma, is the pharmacologically active, major metabolite of clobazam.
Applicazioni
- Impact on bioavailability in epilepsy treatment: A study discussed the implications of N-Desmethylclobazam on drug to drug interactions and neuropsychological impact when used as add-on therapy in drug-resistant epilepsies, highlighting its role in enhancing therapeutic bioavailability (Pietrafusa et al., 2023).
- Research on pharmacokinetic variability: Research explored the pharmacokinetic variability of N-Desmethylclobazam, emphasizing its influence by age, drug interactions, and biochemical markers of toxicity in patients with epilepsy, contributing to a deeper understanding of its pharmacological properties (Heger et al., 2024).
- Evaluation of drug-drug interactions: A comprehensive analysis investigated potential drug-drug interactions between N-Desmethylclobazam and anti-seizure medications, providing insights into its safe and effective use in clinical settings (Gaston et al., 2023).
- Synergistic effects in epilepsy management: A multicenter study on the cenobamate-clobazam interaction revealed both pharmacokinetic interactions and evidence of synergy, underscoring N-Desmethylclobazam′s potential to enhance treatment outcomes in epilepsy (Osborn and Abou-Khalil, 2023).
- Analysis of metabolites in forensic science: Research on the measurement of benzodiazepine receptor agonists′ metabolites, including N-Desmethylclobazam, outlined its detection and concentration levels in urine, offering applications in forensic toxicology (Volkova et al., 2023).
Note legali
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Prodotti correlati
N° Catalogo
Descrizione
Determinazione del prezzo
Avvertenze
Danger
Indicazioni di pericolo
Classi di pericolo
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
Codice della classe di stoccaggio
3 - Flammable liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
35.6 °F - closed cup
Punto d’infiammabilità (°C)
2 °C - closed cup
Scegli una delle versioni più recenti:
Certificati d'analisi (COA)
Lot/Batch Number
It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documenti section.
Se ti serve aiuto, non esitare a contattarci Servizio Clienti
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
A Guberman et al.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 17(3), 311-316 (1990-08-01)
Clobazam, a novel benzodiazepine, was used as an add-on agent in 47 adult patients with intractable epilepsy and a variety of seizure types. A greater than 75% reduction in seizure frequency was observed in 42% (18) of the patients and
Micro-determination of clobazam and N-desmethylclobazam in plasma or serum by electron-capture gas chromatography.
N R Badcock et al.
Journal of chromatography, 421(1), 147-154 (1987-10-09)
W Löscher et al.
European journal of pharmacology, 180(2-3), 255-271 (1990-05-16)
The effects of acute and chronic treatment with the 1,5-benzodiazepine, clobazam, were studied on fully kindled amygdaloid seizures in rats. After acute dosing, clobazam significantly reduced all parameters of kindled seizures (seizure severity, seizure duration, duration of amygdalar afterdischarges) at
J M Streete et al.
Therapeutic drug monitoring, 13(4), 339-344 (1991-07-01)
The analysis of clobazam and its metabolite desmethylclobazam by high-performance liquid chromatography is described. After adding an internal standard 500 microliters of plasma is extracted under basic conditions into dichloroethane. The organic solvent is then evaporated to dryness and the
A H Bardy et al.
Brain & development, 13(3), 174-179 (1991-05-01)
Clobazam was added to the previous antiepileptic drug therapy of 90 children suffering from drug resistant epilepsy. Ten patients became seizure free, although four of these later developed tolerance. Thirty-three patients experienced a decrease in seizure frequency, and 24 of
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.