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890701P

Avanti

14:0 EPC (Cl Salt)

Avanti Research™ - A Croda Brand

Sinonimo/i:

1,2-dimyristoyl-sn-glycero-3-ethylphosphocholine (chloride salt)

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About This Item

Formula empirica (notazione di Hill):
C38H77NO8PCl
Numero CAS:
186492-53-5
Peso molecolare:
742.45
Numero MDL:
MFCD22495357
Codice UNSPSC:
12352211
NACRES:
NA.25

Stato

powder

Confezionamento

pkg of 1 × 10 mg (890701P-10mg)
pkg of 1 × 25 mg (890701P-25mg)

Produttore/marchio commerciale

Avanti Research™ - A Croda Brand

Tipo di lipide

transfection
cationic lipids

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

O=P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCC)=O)OCC.[Cl-]

InChI

1S/C38H77NO8P.ClH/c1-7-10-12-14-16-18-20-22-24-26-28-30-37(40)43-34-36(35-46-48(42,44-9-3)45-33-32-39(4,5)6)47-38(41)31-29-27-25-23-21-19-17-15-13-11-8-2;/h36H,7-35H2,1-6H3;1H/q+1;/p-1/t36-,48?;/m1./s1

Descrizione generale

1,2-dimyristoyl-sn-glycero-3-ethylphosphocholine (14:0 EPC) is an acyl cationic lipid. O-alkyl phosphatidylcholines constitute the first chemically stable tri-esters of biological lipid structures and the first cationic derivatives of phospholipids consisting entirely of biological metabolites linked with ester bonds. The lipid has low toxicity and is biodegradable.

Applicazioni

1,2-dimyristoyl-sn-glycero-3-ethylphosphocholine (14:0 EPC (Cl Salt)) is suitable for use in liposome formulations.

Azioni biochim/fisiol

Synthetic cationic lipids serve as non-viral gene delivery agents. Change in the hydrocarbon chain of phosphatidylcholine (PC) derivatives affects transfection efficiency. 1,2-dimyristoyl-sn-glycero-3-ethylphosphocholine (14:0 EPC) aids in hydration during the formation of liposomes.

Confezionamento

5 mL Clear Glass Sealed Ampule (890701P-10mg)
5 mL Clear Glass Sealed Ampule (890701P-25mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

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William P D Goldring et al.
Bioorganic & medicinal chemistry letters, 22(14), 4686-4692 (2012-06-19)
The synthesis and in vitro evaluation of four cationic lipid gene delivery vectors, characterized by acyclic or macrocyclic, and saturated or unsaturated hydrophobic regions, is described. The synthesis employed standard protocols, including ring-closing metathesis for macrocyclic lipid construction. All lipoplexes
Paria Parvizi et al.
International journal of pharmaceutics, 461(1-2), 145-156 (2013-12-04)
This study seeks correlations between the molecular structures of cationic and neutral lipids, the lipid phase behavior of the mixed-lipid lipoplexes they form with plasmid DNA, and the transfection efficacy of the lipoplexes. Synthetic cationic pyridinium lipids were co-formulated (1:1)
Emile Jubeli et al.
European journal of medicinal chemistry, 125, 225-232 (2016-09-24)
In this communication we describe the construction of four succinic-based cationic lipids, their formulation with plasmid DNA (pDNA), and an evaluation of their in vitro gene delivery into Chinese hamster ovarian (CHO-K1) cells. The cationic lipids employed in this work possess
Rumiana Koynova et al.
The journal of physical chemistry. B, 111(27), 7786-7795 (2007-06-19)
Some mixtures of two cationic lipids including phospholipid compounds (O-ethylphosphatidylcholines) as well as common, commercially available cationic lipids, such as dimethylammonium bromides and trimethylammonium propanes, deliver therapeutic DNA considerably more efficiently than do the separate molecules. In an effort to
Boris G Tenchov et al.
Biochimica et biophysica acta, 1778(10), 2405-2412 (2008-08-30)
Synthetic cationic lipids can be used as DNA carriers and are regarded to be the most promising non-viral gene carriers. For this investigation, six novel phosphatidylcholine (PC) cationic derivatives with various hydrophobic moieties were synthesized and their transfection efficiencies for
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