810602P
Avanti
16:0-7 Doxyl PC
Avanti Research™ - A Croda Brand 810602P, powder
Sinonimo/i:
1-palmitoyl-2-stearoyl-(7-doxyl)-sn-glycero-3-phosphocholine
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About This Item
Formula empirica (notazione di Hill):
C46H90N2O10P
Numero CAS:
Peso molecolare:
862.19
Codice UNSPSC:
41141825
NACRES:
NA.25
Prodotti consigliati
Saggio
>99% (TLC)
Stato
powder
Confezionamento
pkg of 1 × 1 mg (810602P-1mg)
Produttore/marchio commerciale
Avanti Research™ - A Croda Brand 810602P
Tipo di lipide
ESR probes
phospholipids
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
Categorie correlate
Descrizione generale
Avanti′s nitroxide spin product listing is a group of compounds designed to act as membrane probes. A variety of positions down the hydrophobic chain are labeled with the nitroxide functional groups to allow probing the membrane at various depths. These compounds have been synthesized from 1-palmitoyl-2-hydroxy-sn-glycerol-3-phosphocholine with the product being purified by column chromatography. Various n-doxyl phosphocholines have been recently used as biophysical tools to elucidate membrane trafficking with phosphatidylinositol transfer proteins and as fluorescent quenchers in lipid bilayer structural studies.
Phosphatidylcholine (PC), a strong bilayer-forming lipid is the most common phospholipid in mammalian membranes. Several prokaryotic and eukaryotic pathogens has phosphorylcholine as its structural constituent.
Azioni biochim/fisiol
Phosphorylcholine (PC) possesses immunomodulatory properties.
Confezionamento
5 mL Clear Glass Sealed Ampule (810602P-1mg)
Nota sulla preparazione
Product use: To prevent aggregation, prepare water-based solutions of 2 mM stock solutions of n-DOXYL PCs and store in plastic. Dilute stock solutions to 0.03- 0.1 mM solutions for EPR studies. For liposome preparations in fluorescent quenching measurements, dissolve the doxyl lipid in 150 μl absolute ethanol for a concentration of 40.3 mM , Additional supplemental information.
Note legali
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Codice della classe di stoccaggio
11 - Combustible Solids
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
W Harnett et al.
Immunology today, 20(3), 125-129 (1999-04-22)
Phosphorylcholine (PC) is a structural component of a variety of prokaryotic and eukaryotic pathogens. In some cases, PC in infectious agents can benefit the infected host due to its targeting by both the innate and adaptive immune responses. However, as
Delivery of nitroxide spin label to cultured cells by liposomes
Chan HC
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 8, 160-170 (1988)
Phosphatidylserine dynamics in cellular membranes.
Kay, J.G
Molecular Biology of the Cell, 23, 2198-2212 (2012)
Insight into antibody combining sites using nuclear magnetic resonance and spin label haptens
McConnell HM
Advances in Protein Chemistry, 49, 135-148 (1996)
Ultra-stable temperature control in EPR experiments: thermodynamics of gel-to-liquid phase transition in spin-labeled phospholipid bilayers and bilayer perturbations by spin labels
Alaouie AM, et. al.
Journal of Magnetic Resonance, 182, 229-238 (2006)
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