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790310P

Avanti

Transfection Reagent I

Avanti Research™ - A Croda Brand 790310P, powder

Sinonimo/i:

Transfection Reagent I, Transfection Reagent I, contains DOTAP:DOPE (1:1 w/w)

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About This Item

Codice UNSPSC:
12352211
NACRES:
NA.25

Stato

powder

Confezionamento

pkg of 1 × 10 mg (790310P-10mg)
pkg of 2 × 100 mg (790310P-200mg)
pkg of 5 × 100 mg (790310P-500mg)
pkg of 1 × 25 mg (790310P-25mg)

Produttore/marchio commerciale

Avanti Research™ - A Croda Brand 790310P

applicazioni

advanced drug delivery

Tipo di lipide

cationic lipids
transfection

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Categorie correlate

Descrizione generale

Transfection Reagent I comprises the cationic lipid 1,2-dioleoyloxypropyl)-N,N,N-trimethylammonium chloride (DOTAP) and the neutral lipid DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine. DOTAP is a surfactant with double chain quaternary ammonium. The DOTAP/DOPE liposome takes lamellar and inverted hexagonal structures.

Applicazioni

Transfection Reagent I has been used in the preparation of liposomes along with cholesterol for fluorescence-based live-cell imaging studies in the mouse embryonic fibroblasts cells. It may be used for the transfection of DNAzyme (Dz13) into veins.

Azioni biochim/fisiol

Transfection Reagent I is used in large unilamellar cationic vesicles (LUVs) preparation and lipoplex generation. It improves transfection efficiency. DOTAP/DOPE (1,2-dioleoyloxypropyl)-N,N,N-trimethylammonium chloride /(1,2-dioleoyl-sn-glycero-3-phosphoethanolamine) is safe transfection agent for human administration. It inhibits the blood vessel thickening and is a promising candidate for use in coronary artery bypass grafting (CABG).

Confezionamento

5 mL Clear Glass Sealed Ampule (790310P-10mg)
5 mL Clear Glass Sealed Ampule (790310P-200mg)
5 mL Clear Glass Sealed Ampule (790310P-25mg)
5 mL Clear Glass Sealed Ampule (790310P-500mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Codice della classe di stoccaggio

11 - Combustible Solids

Punto d’infiammabilità (°F)

No data available

Punto d’infiammabilità (°C)

No data available

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Yue Li et al.
International journal of cardiology, 168(4), 3659-3664 (2013-07-28)
Coronary artery bypass grafting (CABG) is among the most commonly performed heart surgical procedures. Saphenous vein graft failure due to stenosis impedes the longer-term success of CABG. A key cellular event in the process of vein graft stenosis is smooth
Daniele Pezzoli et al.
Methods in molecular biology (Clifton, N.J.), 1025, 269-279 (2013-08-07)
Efficient delivery of nucleic acids into cells is a promising technique to modulate cellular gene expression for therapeutic and research applications. Cationic lipid-based liposomes represent one of the most intensively studied and employed nonviral vectors. They are positively charged at
DOTAP/DOPE and DC-Chol/DOPE lipoplexes for gene delivery: zeta potential measurements and electron spin resonance spectra
Ciani L, et al.
Biochimica et Biophysica Acta - Biomembranes, 1664(1), 70-79 (2004)
Inhibition of vein graft stenosis with a c-jun targeting DNAzyme in a cationic liposomal formulation containing 1, 2-dioleoyl-3-trimethylammonium propane (DOTAP)/1, 2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)
Li Y, et al.
International Journal of Cardiology, 168(4), 3659-3664 (2013)
Autophagy and formation of tubulovesicular autophagosomes provide a barrier against nonviral gene delivery
Roberts R, et al.
Autophagy, 9(5), 667-682 (2013)
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