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Documenti fondamentali

700121P

Avanti

sitostanol

β-sitostanol, powder

Sinonimo/i:

stigmastanol; dihydrositosterol; (3β)-stigmastan-3-ol; (3β,5α)-stigmastan-3-ol

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About This Item

Formula empirica (notazione di Hill):
C29H52O
Numero CAS:
83-45-4
Peso molecolare:
416.72
Codice UNSPSC:
12352211
NACRES:
NA.25

Saggio

>99% (TLC)

Forma fisica

powder

Confezionamento

pkg of 1 × 5 mg (700121P-5mg)

Produttore/marchio commerciale

Avanti Research™ - A Croda Brand 700121P

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

InChI

1S/C29H52O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h19-27,30H,7-18H2,1-6H3/t20-,21-,22+,23+,24+,25-,26+,27+,28+,29-/m1/s1
LGJMUZUPVCAVPU-HRJGVYIJSA-N

Descrizione generale

It is predominantly present in pine oil.
Sitostanol is a 5α-saturated sitosterol derivative.
Sitostanol is a plant stanol and a hydrogenated form of sitosterol.

Applicazioni

Sitostanol is suitable for its use as a component in micelle preparation, used for cell culture and cellular uptake studies. It is also suitable for use in cell culture to study its effect on a T-helper-1 shift in peripheral blood mononuclear cells (PBMCs) from asthma patients.
Sitostanol may be used in the preparation of binary phospholipid for thermodynamic studies and Brewster angle microscopy studies. It may also be used as a standard steroid in gas chromatography-mass spectrometry(GC-MS).

Azioni biochim/fisiol

Plant stanols are structurally similar to cholesterol, hence it reduces the plasma level of LDL cholesterol. Sitostanol is known to possess hypolipidemic and antiatherogenic effects.
Sitostanol decreases cholesterol absorption. Its ratio with cholesterol is implicated in non-alcoholic fatty liver disease (NAFLD). The ratio also correlates with liver steatosis and inflammation. Sitostanol induces interferon γ production and T-helper response in peripheral blood mononuclear cells (PBMC) in asthma patients. It is a hypocholestremic agent as it decreases the micellar solubility and absorption of cholesterol.
Sitostanol lowers the intestinal absorption of cholesterol and serum cholesterol.

Confezionamento

5 mL Amber Glass Screw Cap Vial (700121P-5mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Comunemente ordinati con questo prodotto

N° Catalogo
Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

11 - Combustible Solids

Certificati d'analisi (COA)

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stigmasterol Avanti Research™ - A Croda Brand

Avanti

700062P

stigmasterol

Brassicasterol from semisynthetic

Sigma-Aldrich

B4936

Brassicasterol

Erythrodiol analytical standard

Supelco

09258

Erythrodiol

β-Sitosterol from soybean, ≥96%

Sigma-Aldrich

S9889

β-Sitosterol

β-Sitosterol primary reference standard

02090580

β-Sitosterol

Uvaol ≥95%

Sigma-Aldrich

U6628

Uvaol

Campesterol ~65%

Sigma-Aldrich

C5157

Campesterol

Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population
Miettinen TA, et al.
The New England Journal of Medicine, 333(20), 1308-1312 (1995)
The influence of plant stanol on phospholipids monolayers-The effect of phospholipid structure
Hkac-Wydro K, et al.
Journal of Colloid and Interface Science, 360(2), 681-689 (2011)
Beneficial effects of sitostanol on the attenuated immune function in asthma patients: results of an in vitro approach
Brull F, et al.
Testing, 7(10), e46895-e46895 (2012)
The essential role of cholesterol metabolism in the intracellular survival of Mycobacterium leprae is not coupled to central carbon metabolism and energy production
Marques MAM, et al.
Journal of Bacteriology, 197(23), 3698-3707 (2015)
2013 IEEE International Conference on Solid Dielectrics (ICSD) IEEE, 131-131 (2006)
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