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700060P

Avanti

desmosterol

Avanti Research™ - A Croda Brand

Sinonimo/i:

24-dehydrocholesterol; 5,24-cholestadien-3β-ol; 110798

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About This Item

Formula empirica (notazione di Hill):
C27H44O
Numero CAS:
313-04-2
Peso molecolare:
384.64
Codice UNSPSC:
12352211
NACRES:
NA.25

Descrizione

3β-hydroxy-5,24-cholestadiene

Saggio

>99% (TLC)

Stato

powder

Confezionamento

pkg of 1 × 10 mg (700060P-10mg)
pkg of 1 × 5 mg (700060P-5mg)

Produttore/marchio commerciale

Avanti Research™ - A Croda Brand

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

InChI

1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
AVSXSVCZWQODGV-DPAQBDIFSA-N

Categorie correlate

Descrizione generale

Desmosterol lacks a double bond between C24 and C25 compared to cholesterol. It is present in the membrane of spermatozoa and astrocytes and is the major brain sterol.

Applicazioni

Desmosterol has been used as a sterol to test its interaction with human protein Mincle and as an internal standard in ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). It may be used as in the preparation of lipid monolayers.

Azioni biochim/fisiol

Desmosterol is a precursor of cholesterol in the Bloch pathway and the enzyme 24-dehydrocholesterol reductase catalyzes this step. Desmosterol accumulates during impairment of 24-dehydrocholesterol reductase enzyme thereby leading to desmosterolosis. Desmosterol is a liver X receptor (LXR) agonist . It is a potential therapeutic target for treating the neurodegenerative disorder. Desmosterol regulates inflammatory signaling in macrophages.

Confezionamento

5 mL Amber Glass Screw Cap Vial (700060P-10mg)
5 mL Amber Glass Screw Cap Vial (700060P-5mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Comunemente ordinati con questo prodotto

N° Catalogo
Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Avanti

700064P

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Sigma-Aldrich

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dihydrolanosterol Avanti Research™ - A Croda Brand

Avanti

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Triparanol ≥97% (HPLC), powder

Sigma-Aldrich

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campesterol Avanti Research™ - A Croda Brand 700126P, powder

Avanti

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campesterol

5α-Cholestan-3β-ol ≥95%

Sigma-Aldrich

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Campesterol ~65%

Sigma-Aldrich

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Sigma-Aldrich

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Stearic acid

María de Las Mercedes Carro et al.
Biochimica et biophysica acta. Biomembranes, 1862(9), 183357-183357 (2020-05-18)
Ram sperm are particularly sensitive to freeze-thawing mainly due to their lipid composition, limiting their use in artificial insemination programs. We evaluated the extent of cholesterol and desmosterol incorporation into ram sperm through incubation with increasing concentrations of methyl-β-cyclodextrin (MβCD)-sterol
Saara Vainio et al.
The Journal of biological chemistry, 281(1), 348-355 (2005-10-27)
Desmosterol is an immediate precursor of cholesterol in the Bloch pathway of sterol synthesis and an abundant membrane lipid in specific cell types. The significance of the difference between the two sterols, an additional double bond at position C24 in
Josi Herron et al.
Current protocols in toxicology, 78(1), e65-e65 (2018-10-16)
Cholesterol and cholesterol-derived oxysterols are critical for embryonic development, synapse formation and function, and myelination, among other biological functions. Indeed, alterations in levels of cholesterol, sterol precursors, and oxysterols result in a variety of developmental disorders, emphasizing the importance of
Guangtao Li et al.
Journal of lipid research, 61(5), 758-766 (2020-01-23)
The formation and properties of liquid-ordered (Lo) lipid domains (rafts) in the plasma membrane are still poorly understood. This limits our ability to manipulate ordered lipid domain-dependent biological functions. Giant plasma membrane vesicles (GPMVs) undergo large-scale phase separations into coexisting

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