700044P
Avanti
7β-hydroxycholesterol-d7
Avanti Polar Lipids
Sinonimo/i:
cholest-5-ene-3b,7b-diol(d7)
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About This Item
Formula empirica (notazione di Hill):
C27H39O2D7
Numero CAS:
Peso molecolare:
409.70
Codice UNSPSC:
12352100
NACRES:
NA.25
Prodotti consigliati
Descrizione
cholest-5-en-3β,7β-diol-d7
Saggio
>99% (TLC)
Forma fisica
powder
Confezionamento
pkg of 1 × 1 mg (700044P-1mg)
Produttore/marchio commerciale
Avanti Polar Lipids
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
Categorie correlate
Descrizione generale
7β-hydroxycholesterol (7βOHC) is an oxidized derivative of cholesterol. 7β-hydroxycholesterol-d7 is the deuterated form of 7β-hydroxycholesterol.
Applicazioni
7β-hydroxycholesterol-d7 has been used:
- as cholesterol oxidation product for mass spectroscopy analysis
- as an internal standard for spiking white adipose tissue and plasma samples for mass spectroscopy analysis
- as an internal standard working solution in gas chromatography- triple-quadrupole mass spectrometry
- as an isotopically labeled internal standard in tandem mass spectroscopy analysis for plasma sterol quantification
Azioni biochim/fisiol
7β-hydroxycholesterol-d7 (7β-OHC) along with 7-ketocholesterol (7-KC) plays a key role in atherogenesis. It is distributed extensively in the arterial compartment of apo- E knockout mice. 7βOHC induces apoptosis via activation of glycogen synthase kinase-3 (GSK3). It also triggers reactive oxygen species (ROS) resulting in mitochondrial dysfunction. 7βOHC favors demyelination and is a potential oxidized oxysterol in X-linked adrenoleukodystrophy (X-ALD) disorder.
Confezionamento
5 mL Amber Glass Screw Cap Vial (700044P-1mg)
Note legali
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Codice della classe di stoccaggio
11 - Combustible Solids
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