936618

(S,R,S)-AHPC-CO-PEG4-C2-amine HCl

≥95%

• Sinonimo/i: (2S,4R)-1-((S)-1-amino-17-(tert-butyl)-15-oxo-3,6,9,12-tetraoxa-16-azaoctadecan-18-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, (2S,4R)-1-[(2S)-2-(1-amino-3,6,9,12-tetraoxapentadecan-15-amido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide hydrochloride
• Formula empirica (notazione di Hill): C₃₃H₅₁N₅O₈S · xHCl
• Numero CAS: 2376139-48-7
• Peso molecolare: 677.85 (free base basis)
• Codice UNSPSC: 12352106
• NACRES: NA.22

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95%
• Forma fisica: crystals (or crystals with chunks)
• Colore: White to Light Yellow
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: C([C@@H](NC(CCOCCOCCOCCOCCN)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1.Cl

Descrizione

Applicazioni

(S,R,S)-AHPC-CO-PEG4-C2-amine HCl is a functionalized functionalized von Hippel-Lindau (VHL) ligand. It contains a terminal amine for conjugation with carboxylic acid linkers. A basic building block for development of a protein degrader library.


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Degrader Building Blocks for Targeted Protein Degradation

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Altre note

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable