Passa al contenuto
Merck
Tutte le immagini(1)

Documenti fondamentali

Visualizza tutta la documentazione

913057

Sigma-Aldrich

Alginate methacrylate

medium viscosity, average degree of methacrylation 25%

Sinonimo/i:

AlMA, AlginateMA, Alginte, Methacrylate-modified alginate, Methacrylated alginate

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula condensata:
(C13H17O10Na)m(C6H7O7Na)n
Codice UNSPSC:
12352201
NACRES:
NA.23

Livello qualitativo

100

Stato

(Powder or chunk(s) or fibers)

Colore

light yellow

Compatibilità

conforms to structure for NMR

Temperatura di conservazione

−20°C

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Applicazioni

Alginate is an anionic polysaccharide that is widely used in pharmaceutical and biomedical applications due to its non-animal origin, low toxicity, biocompatibility, and biodegradability. Alginate hydrogels are commonly used to fabricate tissue engineering scaffolds, bioinks for 3D bioprinting, and nanocarriers for drug & gene delivery. While alginate is commonly crosslinked into a hydrogel via ionic-crosslinking with divalent cations (e.g., Ca2+), these gels feature limited long-term stability due to exchange reactions and migration of divalent cations from the alginate matrix. To prevent matrix degradation, alginate can be functionalized with reactive groups that can be chemically crosslinked, such as methacrylates. Methacrylate-functionalized alginate can be used to prepare hydrogels by thermal or photochemical crosslinking of the terminal methacrylates. Properties of the resulting hydrogel (e.g., stiffness, swelling ratio, rate of degradation) can be tuned by alginate molecular weight, degree of methacrylate functionalization, and crosslink density.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documenti section.

Se ti serve aiuto, non esitare a contattarci Servizio Clienti

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Photocrosslinkable polysaccharides for in situ hydrogel formation
Journal of Biomedical Materials Research Part A, 54 (1), 115-112 (2001)
Alginate derivatization: A review of chemistry, properties and applications
Biomaterials, 33, 3279-3305 (2012)
Andrew D Rouillard et al.
Tissue engineering. Part C, Methods, 17(2), 173-179 (2010-08-14)
Methods for seeding high-viability (>85%) three-dimensional (3D) alginate-chondrocyte hydrogel scaffolds are presented that employ photocrosslinking of methacrylate-modified alginate with the photoinitiator VA-086. Comparison with results from several other photoinitiators, including Irgacure 2959, highlights the role of solvent, ultraviolet exposure, and
Oju Jeon et al.
Biomaterials, 30(14), 2724-2734 (2009-02-10)
Photocrosslinked and biodegradable alginate hydrogels were engineered for biomedical applications. Photocrosslinkable alginate macromers were prepared by reacting sodium alginate and 2-aminoethyl methacrylate in the presence of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride and N-hydroxysuccinimide. Methacrylated alginates were photocrosslinked using ultraviolet light with 0.05% photoinitiator.
Jia Jia et al.
Acta biomaterialia, 10(10), 4323-4331 (2014-07-08)
Recent advances in three-dimensional (3-D) printing offer an excellent opportunity to address critical challenges faced by current tissue engineering approaches. Alginate hydrogels have been used extensively as bioinks for 3-D bioprinting. However, most previous research has focused on native alginates
Visualizza tutti i documenti correlati

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.