901376

Polyester bis-MPA dendron

no. Surface Groups 8, 8 acetylene, 1 NHBoc (core), generation 3

• Sinonimo/i: PFd-G3-BOCNH-Acetylene, bis-MPA dendron
• Formula empirica (notazione di Hill): C₁₀₇H₁₃₅NO₅₃
• Peso molecolare: 2283.19
• Codice UNSPSC: 12162002
• NACRES: NA.23

Proprietà

• Livello qualitativo: 100
• Stato: solid
• PM: generation 3
• N° gruppi superficiali: 8
• Colore: white to off-white
• Temperatura di conservazione: −20°C

Descrizione

Descrizione generale

• Polymer architecture: Dendron
• Generation: 3
• Core functional group: Boc-protected amine
• End Group Functionality: Alkyne
• No. Surface Groups: 8
• Calculated Mol. Wt.: 2283.21 g/mol
• Boc : tert-Butyloxycarbonyl
• bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid

Polyester bis-MPA dendron (8 acetylene, 1 NHBoc (core), generation 3), a high generation dendron, is synthesized by using anhydride activated bis-MPA monomers via divergent growth. It has a large and exact number of reactive groups and has dual functionalization capacity that makes it useful as a high-value scaffold.

Applicazioni

Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. These alkyne-functionalized dendrimers can be readily functionalized using either copper(I)-catalysed alkyne-azide cycloaddition (CuAAC), strain-promoted alkyne-azide cycloaddition (SPAAC), or thiol-yne click reactions. Additionally, the amine-functionalized core can be readily used in EDC or DCC coupling reactions (after Boc deprotection) with carbonyl-containing compounds to yield highly functionalized materials for a variety of biomedical applications.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable