804568

(R,S)-Bode Kinetic Resolution Catalyst

• Sinonimo/i: (4aR,9aS)-6-Bromo-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one
• Formula empirica (notazione di Hill): C₁₁H₁₀BrNO₃
• Numero CAS: 1394957-71-1
• Peso molecolare: 284.11
• Codice UNSPSC: 12352101
• ID PubChem: 329768882
• NACRES: NA.22

Proprietà

• Forma fisica: solution
• Livello qualitativo: 100
• Gruppo funzionale: bromo; ether
• Temperatura di conservazione: 15-25°C
• Stringa SMILE: O=C(CO1)N(O)[C@@]2([H])[C@]1([H])CC3=CC=C(Br)C=C32
• InChI: 1S/C11H10BrNO3/c12-7-2-1-6-3-9-11(8(6)4-7)13(15)10(14)5-16-9/h1-2,4,9,11,15H,3,5H2/t9-,11+/m0/s1; FQXSUQCCAHKURK-GXSJLCMTSA-N

Descrizione

Applicazioni

The following hydroxamic acid catalyst was shown by Bode and coworkers to assist in the kinetic resolution of cyclic amines through acylation of one enantiomer, which can be controlled using either the (R or S)- or (S or R)-Bode Kinetic Resolution Catalyst, both of which are also available through Sigma-Aldrich.
It can also be employed in the preparation of nonracemic piperidines by kinetic resolution using an α-hydroxy-α′, β-unsaturated ketone in the presence of a pyrrolotriazolium salt.

Altre note

Expanded substrate scope and catalyst optimization for the catalytic kinetic resolution of N-heterocycles

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Consigli di prudenza: P301 + P312 + P330
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable