790435

TCO PEG4 succinimidyl ester

• Sinonimo/i: trans-Cyclooctene-PEG4-NHS
• Formula empirica (notazione di Hill): C₂₄H₃₈N₂O₁₀
• Peso molecolare: 514.57
• Numero MDL: MFCD28118912
• Codice UNSPSC: 12352108
• ID PubChem: 329768214
• NACRES: NA.22

Proprietà

• Forma fisica: liquid
• Impiego in reazioni chimiche: reaction type: click chemistry; reagent type: linker
• Gruppo funzionale: NHS ester
• Temperatura di conservazione: −20°C
• Stringa SMILE: O=C(NCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)OC2CCC/C=C/CC2
• InChI: 1S/C24H38N2O10/c27-21-8-9-22(28)26(21)36-23(29)10-12-31-14-16-33-18-19-34-17-15-32-13-11-25-24(30)35-20-6-4-2-1-3-5-7-20/h1-2,20H,3-19H2,(H,25,30)/b2-1+; ZKPMRASGLDBKPF-OWOJBTEDSA-N

Descrizione

Applicazioni

Succinimidyl ester/NHS (amine reactive) functionalized trans-cyclooctene derivative for incorporation of the cyclooctene moiety into amine containing compounds or biomolecules. Trans-cyclooctenes are useful in strain-promoted, copper-free, click chemistry cycloaddition reactions with 1, 2, 4, 5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules, without the need for a catalyst, to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported, and has had many applications in biological labeling and imaging. The PEG spacer allows for increased water solubility, less aggregation, and an increased distance between the amine to be modified and the reactive alkene.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable