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765511

Sigma-Aldrich

Gold nanoparticles

20 nm diameter, carboxylic acid functionalized, PEG 5000 coated, OD 50, dispersion in H2O

Sinonimo/i:

Gold nanoparticles COOH functionalized, Au NP COOH, Gold Colloid

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About This Item

Codice UNSPSC:
12162002
NACRES:
NA.23

Materiali

PEG 5000

Forma fisica

dispersion in H2O
nanoparticles

Confezionamento

poly bottle of 1 mL

OD

50

Diametro

20 nm

pH

6.0-8.0 (25 °C)

Solubilità

water: miscible

Densità

1.00 g/cm3

λmax

520 nm

Gruppo funzionale

carboxylic acid

Temperatura di conservazione

2-8°C

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Descrizione generale

Carboxylic acid functionalized GNPs form conjugates with various protein molecules due to the electrostatic attraction between negatively charged carboxylate groups and positively charged amino groups of protein.

Applicazioni

Carboxylic acid functionalized, PEG 5000 coated, OD 50, and H2O dispersed gold nanoparticles can be potentially used in the development of biosensors, cancer-cell imaging, drug delivery, and photothermal therapy.
AuNPs may be used to prepare SARS-CoV-2 conjugate for COVID-19 detection using lateral flow immunoassay technique. It may also be used in the immobilization of antibodies to improve the sensitivity of optical fiber sensors for the screening of COVID-19. It can also be deposited on the titanium electrode for the formation of a miniaturized device for the electrochemical detection of DNA hybridization.
The carboxylic acid group binds with various proteins and can be used in targeted drug delivery and gene therapy.
Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.

Caratteristiche e vantaggi

Decreases the cytotoxicity and increases efficiency of GNPs in targeted drug delivery. The PEG increases the stability of the nanoparticles and prevents agglomeration.

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Size-dependent in vivo toxicity of PEG-coated gold nanoparticles
Zhang X, et al.
International journal of nanomedicine, 6, 2071-2071 (2011)
Nishima Wangoo et al.
Journal of colloid and interface science, 323(2), 247-254 (2008-05-20)
We report a novel strategy for the synthesis of aqueous stable, carboxylated gold nanoparticles (GNPs) by using glutamic acid as the reducing agent. The ratio of chloroaurate ions, AuCl(-)(4) to glutamic acid was optimized in the reaction medium to obtain
Recent advances in nanoparticle-based lateral flow immunoassay as a point-of-care diagnostic tool for infectious agents and diseases
Banerjee R and Jaiswal A
Analyst, 143(9), 1970-1996 (2018)
Functionalized gold nanoparticles and their biomedical applications
Tiwari, P. M., Vig, K., Dennis, V. A., & Singh, S. R.
Nanomaterials, 1(1), 31-63 (2011)

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