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Documenti fondamentali

391522

Sigma-Aldrich

α-Methylhydrocinnamic acid

98%

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About This Item

Formula condensata:
C6H5CH2CH(CH3)CO2H
Numero CAS:
Peso molecolare:
164.20
Numero MDL:
Codice UNSPSC:
12352100
ID PubChem:
NACRES:
NA.22

Saggio

98%

Stato

solid

P. ebollizione

167-168 °C/23 mmHg (lit.)

Punto di fusione

39-41 °C (lit.)

Densità

1.065 g/mL at 25 °C (lit.)

Gruppo funzionale

carboxylic acid
phenyl

Stringa SMILE

CC(Cc1ccccc1)C(O)=O

InChI

1S/C10H12O2/c1-8(10(11)12)7-9-5-3-2-4-6-9/h2-6,8H,7H2,1H3,(H,11,12)
MCIIDRLDHRQKPH-UHFFFAOYSA-N

Categorie correlate

Descrizione generale

α-Methylhydrocinnamic acid (2-methyl-3-phenylpropionic acid, 2-benzylpropionic acid) is a cinnamic acid derivative. Its synthesis by the asymmetric hydrogenation of α-methylcinnamic acid has been reported. α-Methylhydrocinnamic acid, a short chain fatty acid derivative (SCFAD), has been reported to correct the cystic fibrosis transmembrane conductance regulator (ΔF508-CFTR) defect. Conformational studies of 2-methyl-3-phenylpropionic acid has been investigated by NMR spectroscopy. The enantiomers of 2-benzylpropionic acid has been reported to be synthesized using a lipase-catalyzed resolution. (S) (+)-2-methyl-3-phenylpropionic acid participates in the synthesis of optically active (R)-5-methyl-6-phenylhexanoyl azide. L-2-Methyl-3.phenylpropionic acid has been reported to be an inhibitor of carboxypeptidase A. Polymer-supported “Evans” oxazolidinone mediated solid phase asymmetric has been employed in the synthesis of (S)-2-methyl-3-phenylpropionic acid.

Applicazioni

α-Methylhydrocinnamic acid is suitable for use in the comparative study to investigate the γ-globin inducibility of short-chain fatty acid derivatives (SCFADs) in mice. It may be used as a histone deacetylase (HDAC) inhibitor in the comparative study to investigate the EGFP-induction potency of a number of HDAC inhibitors. It may be used in the study to investigate the selectivity of the sensor based on imprinted poly(o-phenylenediamine) (iPoPD).

Pittogrammi

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Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

235.4 °F - closed cup

Punto d’infiammabilità (°C)

113 °C - closed cup

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves


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H Peng et al.
The Analyst, 126(2), 189-194 (2001-03-10)
The preparation and characterization of electrosynthesized poly(o-phenylenediamine) (iPoPD) as a molecular imprinting material were studied by an in situ quartz crystal impedance method. The changes of delta f0, delta R1, delta L1 and delta C0 suggest that the polymer film
A potent reversible inhibitor of carboxypeptidase A.
L D Byers et al.
The Journal of biological chemistry, 247(2), 606-608 (1972-01-25)
The preparation and first application of a polymer-supported ?Evans? oxazolidinone.
Allin SM and Shuttleworth SJ.
Tetrahedron Letters, 37(44), 8023-8026 (1996)
H Bohner et al.
International journal of clinical pharmacology and therapeutics, 35(3), 117-122 (1997-03-01)
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Yishan Liu et al.
Journal of hazardous materials, 192(3), 1633-1640 (2011-07-29)
Microbial degradation of the chiral 2-phenylbutyric acid (2-PBA), a metabolite of surfactant linear alkylbenzene sulfonates (LAS), was investigated using both racemic and enantiomer-pure compounds together with quantitative stereoselective analyses. A pure culture of bacteria, identified as Xanthobacter flavus strain PA1

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