Intensified and Continuous Downstream Processing
Gain operational efficiency and flexibility while reducing footprint and costs
Looking to increase your downstream process efficiency?
Transformation of the biomanufacturing workflow is being accelerated by the demand for new therapeutics combined with the need to reduce costs while ensuring operational flexibility and productivity.
Process intensification, closed, and continuous bioprocessing are foundational strategies for achieving these goals. They are widely and successfully deployed in the downstream suite to be more efficient, faster, smaller, less expensive, and sustainable.
To help biopharmaceutical manufacturers intensify, closing, digitally-enhance, or go fully continuous with their processes and gain new levels of operational efficiency and flexibility, there are multiple levers within the DSP suite.
Flow-Through Polishing Chromatography
Polishing chromatography occurs post viral inactivation of mAb downstream processing to remove any remaining impurities from the monoclonal antibody feed stream. In traditional batch processes, polishing steps comprise nearly 25% of the cost of production. Integrating individual polishing steps into a single, continuous flow-through process delivers increased efficiency and yields while reducing costs by up to 10%. This intensified approach lowers the overall footprint through the elimination of intermediate hold tanks, buffer consumption reduction, and the removal of product dilution steps. Overhead costs such as operator intervention are further reduced by the integration of process control systems.
- Eshmuno® CP-FT Resin, designed to provide efficient removal of mAb aggregates in the flow-through frontal chromatography mode of operation enabling loading capacities 10× higher than traditional bind/elute CEX chromatography.
- Natrix® Q Chromatography Membrane, a high capacity, high throughput strong anion exchange membrane adsorber designed to purify biomolecules in flow-through operating conditions.
Related Categories
Single-use and multi-use chromatography systems are critical for the separation of your valuable molecules.
Affinity chromatography is often used during the capture phase to isolate the target molecule and reduce process volume.
Ion exchange (IEX) chromatography separates biomolecules based on difference in charge between the target molecule and chromatography resin.
Optimize downstream purification using membrane chromatography for capture and polishing. Natrix membranes boost economics and facility efficiency.
Elevate Filtration Precision: Our tangential flow products ensure purity for mAbs, vaccines, and more, scaling from single-use to multi-use.
Related Resources
- What is Multi Column Chromatography?
In this article, we will discuss one of the methods used to intensify the capture chromatography process: multi column chromatography (MCC).
- Mobius® Multi Column Capture System
The Mobius® Multi Column Capture system is designed as a fully automated, single-use solution to operate continuous closed capture chromatography.
- App Note: Multi Column Capture
Results from the multi-column capture (MCC) system implementation as part of a fully integrated downstream continuous manufacturing platform are reported here.
- Intensified Polishing Using Single-Pass Tangential Flow Filtration (SPTFF) with Anion Exchange Chromatography
In this app note, SPTFF preconcentration is used to intensify the anion exchange (AEX) polishing step in monoclonal antibody (mAb) processing for improved impurity removal and column productivity.
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