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Merck

ERBB2

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2

Sinonimi:
CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
Specie:
ID UniProtKB:
ID gene:
  • Human(2064) Summary: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
  • Mouse(13866) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • Rat(24337) v-erb-b2 avian erythroblastic leukemia viral oncogene 2
  • sheep(780519) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • Domestic Rabbit(100009554) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • naked mole-rat(101705227) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • domestic guinea pig(100727657) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • Zebrafish(386966) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
  • cow(505709) v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
  • Horse(100054739) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • domestic cat(751824) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • dog(403883) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • chicken(426130) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

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ELISA

N° Catalogo
Descrizione
Specie
Human ErbB2 / HER2 ELISA Kit, for serum, plasma, cell culture supernatant and urine,
Specie
human
Phosphotyrosine ERBB2 / Receptor Tyrosine-protein Kinase erbB-2 ELISA Kit, ,
Specie
human

Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-ERBB2 antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunofluorescence
immunohistochemistry

western blot
Monoclonal Anti-c-erbB-2 antibody produced in mouse, ~2 mg/mL, clone HER2-96, purified immunoglobulin, buffered aqueous solution,
Reattività con
human
Applicazione
ELISA
immunoprecipitation (IP)

microarray
Anti-c-ErbB2/c-Neu (Ab-3) Mouse mAb (3B5), liquid, clone 3B5, Calbiochem®,
Reattività con
human, mouse
Applicazione
Anti-C-ERBB-2/HER-2 antibody, Rabbit monoclonal, recombinant, expressed in proprietary host, clone SP3, tissue culture supernatant,
Reattività con
dog, hamster, human, mouse, rat
Applicazione
immunohistochemistry
Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody, Upstate®, from rabbit,
Reattività con
human, rat
Applicazione
immunocytochemistry
western blot

Small Molecule - Inhibitor

N° Catalogo
Descrizione
Specie
Mubritinib, ≥98% (HPLC),
Specie
human
CP724714, ≥98% (HPLC),
Specie
human
Lapatinib, ≥98% (HPLC),
Specie
human
Lapatinib, ,
Specie
human
Tyrphostin AG 879, 99% (HPLC),
Specie
human

Proteins

N° Catalogo
Descrizione
Specie
HER2 (676-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Specie
human

esiRNA

N° Catalogo
Descrizione
Specie
MISSION® esiRNA, targeting human ERBB2,
Specie
human
MISSION® esiRNA, targeting mouse Erbb2,
Specie
mouse