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MilliporeSigma

EGFR

epidermal growth factor receptor

Sinonimi:
ERBB, ERBB1, HER1, PIG61, mENA
Specie:
Human EGFR (1956), Mouse Egfr (13649), Rat Egfr (24329), fruit fly Egfr (37455), cow EGFR (407217), Horse EGFR (100067755), domestic cat EGFR (100510799), dog EGFR (404306), chicken EGFR (396494), domestic guinea pig Egfr (100725363) ...Più
ID UniProtKB:
P00533, O00688, O00732, P06268, Q14225, Q68GS5, Q92795, Q9BZS2
ID gene:
  • Human(1956) Summary: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
  • Mouse(13649) epidermal growth factor receptor
  • Rat(24329) epidermal growth factor receptor
  • fruit fly(37455) Epidermal growth factor receptor
  • cow(407217) epidermal growth factor receptor
  • Horse(100067755) epidermal growth factor receptor
  • domestic cat(100510799) epidermal growth factor receptor
  • dog(404306) epidermal growth factor receptor
  • chicken(396494) epidermal growth factor receptor
  • domestic guinea pig(100725363) epidermal growth factor receptor
  • naked mole-rat(101723771) epidermal growth factor receptor
  • sheep(780479) epidermal growth factor receptor

Custom & Knockdown Gene Products

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  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

ELISA

N° Catalogo
Descrizione
Specie
RAB0160
Human EGFR / ErbB1 ELISA Kit, for serum, plasma, cell culture supernatants and urine,
Specie
human
RAB0165
Phospho-EGFR (pTyr1068) ELISA Kit, for detection of human phospho-egfr (pTyr1068) in cell and tissue lysates,
Specie
human
RAB0166
Phospho-EGFR (pTyr1068) and pan-EGFR ELISA Kit, for detection of human phospho-egfr (pTyr1068) and pan-egfr in cell and tissue lysates,
Specie
human
RAB0151
Cell-Based ELISA for detecting phospho-EGFR, in cultured cell lines, 96 assays,
Specie
human
RAB0941
Phosphotyrosine EGFR / Epidermal Growth Factor Receptor ELISA Kit, ,
Specie
human

Small Molecule - Antagonist

N° Catalogo
Descrizione
Specie
T4182
Tyrphostin AG 1478, ≥98%,
Specie
human, mouse
S8442
SU 5416, ≥98% (HPLC),
Specie
human, mouse
G6649
Genistein, synthetic, ≥98% (HPLC), powder,
Specie
mouse, human, rat
G6776
Genistein, from Glycine max (soybean), ~98% (HPLC),
Specie
mouse, human, rat

Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
SAB4702025
Monoclonal Anti-EGFR PE produced in mouse, ,
Reattività con
horse
Applicazione
flow cytometry
MABS1915M
Anti-EGFRvIII Antibody, clone DH8.3, clone DH8.3, from mouse,
Reattività con
human
Applicazione
ELISA
flow cytometry
immunohistochemistry
immunoprecipitation (IP)
western blot
05-104
Anticorpo anti-EGFR, clone LA22, clone LA22, Upstate®, from mouse,
Reattività con
human
Applicazione
immunocytochemistry
immunoprecipitation (IP)
western blot
E2906
Anti-dEGF Receptor, Extracellular Domain antibody, Mouse monoclonal, clone C-273, purified from hybridoma cell culture,
Reattività con
drosophila
Applicazione
ELISA
immunohistochemistry
western blot
05-101
Anti-EGFR Antibody, neutralizing, clone LA1, clone LA1, Upstate®, from mouse,
Reattività con
human
Applicazione
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
neutralization
western blot

Small Molecule - Inhibitor

N° Catalogo
Descrizione
Specie
SML1657
Gefitinib, ≥98% (HPLC),
Specie
human
CDS022564
Erlotinib hydrochloride, ,
Specie
human
D3943
DAPH, ≥98% (HPLC), solid,
Specie
human
T7040
Tyrphostin 1, ≥98%,
Specie
human
Y0001813
Gefitinib, European Pharmacopoeia (EP) Reference Standard,
Specie
human

Proteins

N° Catalogo
Descrizione
Specie
E2645
Epidermal Growth Factor Receptor human, lyophilized powder, ≥15,000 units/mg protein (Bradford),
Specie
human
SRP0239
EGFR Active human, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
Specie
human
SRP0242
EGFR (T790M L858R) Active human, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
Specie
human
SRP3028
EGF-receptor human, recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture,
Specie
human
E3641
Epidermal Growth Factor Receptor human, buffered aqueous glycerol solution, 5,000-30,000 units/mg protein (Lowry),
Specie
human

esiRNA

N° Catalogo
Descrizione
Specie
EHU076761
MISSION® esiRNA, targeting human EGFR,
Specie
human
EMU075311
MISSION® esiRNA, targeting mouse Egfr,
Specie
mouse