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Key Documents

SRP0160

Sigma-Aldrich

Histone H3 peptide (21-44) human

≥90% (HPLC)

Synonym(s):

HIST1H3E, Histone H3.1

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

Assay

≥90% (HPLC)

form

aqueous solution

mol wt

~2 kDa

packaging

pkg of 160 nmol

storage condition

avoid repeated freeze/thaw cycles

concentration

>0.02 mg/mL

NCBI accession no.

NM_003532

UniProt accession no.

P68431

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... HIST1H3E(8353)

General description

A peptide substrate for Histone 3 K27 methyltransferases.

Application

Study enzyme kinetics, and screen small molecular inhibitors of Histone 3 K27 methyltransferases for drug discovery and HTS applications

Physical form

Supplied as water solution, 800 μM

Preparation Note

Thaw on ice. Upon first thaw, briefly spin tube to recover full content of the tube. Aliquot into single use aliquots. Store remaining product in aliquots at -70°C. Note: Avoid freeze/thaw cycles.

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Articles

Histone Modification and Chromatin Remodeling | Epigenetics

Epigenetic modifications are thought to occur through two key interconnected processes—DNA methylation and the covalent modification of histones.

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