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SML2461

Sigma-Aldrich

LM22B-10

≥98% (HPLC)

Synonym(s):

2,2′,2′′,2′′′-[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakis[ethanol], 2,2′,2′,2′′′-[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakisethanol

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About This Item

Empirical Formula (Hill Notation):
C27H33ClN2O4
CAS Number:
342777-54-2
Molecular Weight:
485.01
MDL number:
MFCD00483554
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

faint blue to green

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

ClC1=CC=C(C(C2=CC=C(N(CCO)CCO)C=C2)C3=CC=C(N(CCO)CCO)C=C3)C=C1

Biochem/physiol Actions

LM22B-10 is a brain penetrant, potent and selective TrkB and TrkC neurotrophin receptors agonist that improves cell survival and potently accelerated neurite outgrowth. LM22B-10 inhibits binding of BDNF to TrkB-expressing cells and NT-3 to TrkC-expressing cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Tao Zhang et al.
Asian Pacific journal of tropical medicine, 10(12), 1172-1176 (2017-12-23)
To study the influence of glycyrrhetinic acid (GA) on bronchial asthma (BA) smooth muscle proliferation and apoptosis as well as inflammatory factor expression and its molecular mechanism. Male SD guinea pigs were selected and made into asthma models, bronchial asthma
Tao Yang et al.
Neuropharmacology, 110(Pt A), 343-361 (2016-06-24)
Neurotrophin (NT) receptors are coupled to numerous signaling networks that play critical roles in neuronal survival and plasticity. Several non-peptide small molecule ligands have recently been reported that bind to and activate specific tropomyosin-receptor kinase (Trk) NT receptors, stimulate their

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