SML1299
TC-2153
≥95% (HPLC)
Synonym(s):
8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride, TC 2153
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About This Item
Empirical Formula (Hill Notation):
C7H4F3NS5 · HCl
CAS Number:
Molecular Weight:
355.89
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear
shipped in
wet ice
storage temp.
−20°C
Biochem/physiol Actions
TC-2153 is a potent inhibitor of STEP (STriatal-Enriched protein tyrosine Phosphatase) that forms a reversible covalent bond with the catalytic cysteine in STEP. TC-2153 increases tyrosine phosphorylation of STEP substrates ERK1/2, Pyk2, and GluN2B in cell cultures. TC-2153 improves cognitive function in transgenic AD mice.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Ebbe T Poulsen et al.
Frontiers in molecular neuroscience, 10, 59-59 (2017-04-01)
Alzheimer's disease (AD) is the most common cause of dementia and is likely caused by defective amyloid precursor protein (APP) trafficking and processing in neurons leading to amyloid plaques containing the amyloid-β (Aβ) APP peptide byproducts. Understanding how APP is
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