SML1291

Frovatriptan succinate monohydrate

≥97% (HPLC)

• Synonym(s): Frovatriptan succinate, R-(+) 3-Methylamino-6-carboxamido-1,2,3,4-tetrahydrocarbazole monosuccinate monohydrate
• Empirical Formula (Hill Notation): C₁₄H₁₇N₃O · C₄H₆O₄ · H₂O
• CAS Number: 158930-17-7
• Molecular Weight: 379.41
• MDL number: MFCD18251278
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825767
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥97% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: OC(CCC(O)=O)=O.NC(C(C=C1)=CC2=C1NC3=C2C[C@H](NC)CC3)=O.O
• InChI: 1S/C14H17N3O.C4H6O4.H2O/c1-16-9-3-5-13-11(7-9)10-6-8(14(15)18)2-4-12(10)17-13;5-3(6)1-2-4(7)8;/h2,4,6,9,16-17H,3,5,7H2,1H3,(H2,15,18);1-2H2,(H,5,6)(H,7,8);1H2/t9-;;/m1../s1
• InChI key: CUETXFMONOSVJA-KLQYNRQASA-N
• Gene Information: human ... HTR1B(3351) , HTR1D(3352)

Description

Biochem/physiol Actions

During migraine condition, frovatriptan succinate monohydrate acts on extra cerebral, intracranial arteries and prevent excessive dilation of these vessels.

Frovatriptan is a serotonin 5HT-1B/1D-receptor agonist used to treat migraine. Frovatriptan has high affinity for the 5-HT(1B) and 5-HT(1D) receptors while affinity for 5-HT receptors other than 5-HT(1B/1D) is substantially lower with a pEC₅₀ value of 8.2 for the 5-HT1B receptor, compared to a pEC₅₀ value of 6.2 for the 5-HT7 receptor.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable