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Key Documents

SML0885

Sigma-Aldrich

bpV(pic)

≥95% V basis

Synonym(s):

Dipotassium Bisperoxovanadium(pic) dihydrate, Dipotassium bisperoxo (picolinato) oxovanadate (V) dihydrate, K2 [VO(O2)2C6H4NO2] · 2 H2O

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About This Item

Empirical Formula (Hill Notation):
K2VOO2O2C6H4NO2 · 2H2O
CAS Number:
148556-27-8
Molecular Weight:
367.27
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥95% V basis

form

powder

storage condition

protect from light

color

faintly yellow to dark yellow

solubility

H2O: 20 mg/mL, clear

storage temp.

−20°C

Application

bpV(pic) has been used in cell culture treatment to study the route of activation of multiple pathways required for HERV (human endogenous retroviruses) transcription.

Biochem/physiol Actions

bpV(pic) contains a polar side chain, and specifically inhibits PTEN(phosphatase and tensin homolog) unlike its parent compound, which targets several other phosphatases too. Thus, making bpV(pic) more a prefered inhibitor. bpV(pic) is recognized as a potent activator of multiple sclerosis (an autoimmune disorder) related human endogenous retroviruses.
bpV(pic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for phosphatase and tensin homolog (PTEN), a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(pic) are 31 nM for PTEN compared to 12.7 μM for PTPβ and 61 μM for PTP-1β. bpV(pic) can also act as an insulin mimetic and activate insulin receptor kinase (IRK).

Other Notes

Light Sensitive

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315 - H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Compound signaling activates endogenous retroviruses by inducing enhancer and gene-neighborhood transcription.
Azebi S, et al.
bioRxiv, 284695 (2018)
Phosphatase and tensin homologue deleted on chromosome ten (PTEN) as a molecular target in lung epithelial wound repair.
Lai J P, et al.
British Journal of Pharmacology, 152(8), 1172-1184 (2007)
Junmei Wang et al.
Molecular brain, 14(1), 155-155 (2021-10-13)
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease, with no present cure. The progressive loss of MNs is the hallmark of ALS. We have previously shown the therapeutic effects of the phosphatase and tensin homolog (PTEN)

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