SAB4700031
Monoclonal Anti-CD1A-PE antibody produced in mouse
clone HI149, purified immunoglobulin, buffered aqueous solution
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.44
biological source
mouse
Quality Level
conjugate
phycoerythrin (R-PE) conjugate
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
HI149, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
flow cytometry: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... CD1A(909)
General description
CD1a molecule is a lipid-presenting protein, which is highly expressed on Langerhans cells. It belongs to the CD1 protein family and is encoded by the gene mapped to human chromosome 1.
The antibody HI149 reacts with CD1a (T6), a 49 KDa polypeptide associated with beta2-microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells and some T cell leukemias and lymphomas. The antibody does not react with peripheral blood T and B lymphocytes, monocytes, granulocytes, platelets and erythrocytes.
Immunogen
Human thymocytes
Application
The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.
Biochem/physiol Actions
CD1a acts as a potential target for treatment against inflammatory skin diseases. The encoded protein functions as a phenotypic marker of human epidermal Langerhans cells (LC). CD1a mediates the presentation of lipids to induce T cell activation resulting in the production of interleukin-22 (IL-22), IL-13 and interferon (IFN)γ.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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HLA class I molecules are associated with CD1a heavy chains on
normal human thymus cells
Amiot M
Proceedings of the National Academy of Sciences of the USA, 85, 4451-4454 (1988)
CD1a on Langerhans cells controls inflammatory skin disease.
Kim JH
Nature Immunology, 17, 1159-1166 (2016)
Immunological profiling of patients with ulcerative colitis leads to identification of two inflammatory conditions and CD1a as a disease marker
Fohlinger M
Journal of Translational Medicine, 14, 310-310 (2016)
Catherine E Angel et al.
International immunology, 19(11), 1271-1279 (2007-09-07)
We recently demonstrated that three antigen-presenting cell (APC) subsets exist in the healthy human dermis, CD14(+) and CD1a(+) dermal APCs and migratory dermal Langerhans cells. Here, we extend these findings by defining CD208 as an exclusive marker of migratory dermal
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