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Key Documents

SAB2500236

Sigma-Aldrich

Anti-Choline acetyltransferase antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Acetyl CoA:choline O-acetyltransferase, Anti-CHAT, Anti-CMS1A, Anti-CMS1A2

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About This Item

MDL number:
MFCD01321843
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

canine, chimpanzee, human, pig

technique(s)

indirect ELISA: suitable
western blot: suitable

UniProt accession no.

P28329

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CHAT(1103)

General description

Choline acetyltransferase (CHAT) has a molecular weight of about 68kDa. It is synthesized in the parakaryon and is transported to the axon terminals. CHAT is part of the choline/carnitine acyltransferase family.

Immunogen

Peptide with sequence CKEKATRPSQGHQP from the C Terminus of the protein sequence according to NP_065574; NP_066264; NP_066265; NP_066266.

Biochem/physiol Actions

Choline acetyltransferase (CHAT) is involved in the synthesis of acetylcholine in neurons. It catalyzes the transfer of an acetyl group between acetyl-coenzyme A and choline. Mutations in the gene encoding this protein have been associated with congenital neuromuscular disorders.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Choline acetyltransferase structure reveals distribution of mutations that cause motor disorders
The Embo Journal (2004)
Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase.
Olofsson PS, e.al
Nature Biotechnology (2016)
Jessica A Ash et al.
Neurobiology of disease, 70, 32-42 (2014-06-17)
Down syndrome (DS) is marked by intellectual disability (ID) and early-onset of Alzheimer's disease (AD) neuropathology, including basal forebrain cholinergic neuron (BFCN) degeneration. The present study tested the hypothesis that maternal choline supplementation (MCS) improves spatial mapping and protects against
J J Roland et al.
Brain structure & function, 219(4), 1231-1237 (2014-06-27)
The medial septum and diagonal band of Broca (MSDB) influence hippocampal function through cholinergic, GABAergic, and glutamatergic septohippocampal neurons. Non-selective damage of the MSDB or intraseptal scopolamine impairs classical conditioning of the eyeblink response (CCER). Scopolamine preferentially inhibits GABAergic MSDB
Irene E Whitney et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(30), 10109-10121 (2014-07-25)
The retina contains two populations of cholinergic amacrine cells, one positioned in the ganglion cell layer (GCL) and the other in the inner nuclear layer (INL), that together comprise ∼1/2 of a percent of all retinal neurons. The present study
View All Related Papers

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