PZ0205

CE-178253 benzenesulfonate salt

≥98% (HPLC)

• Synonym(s): 1-[7-(2-Chlorophenyl)-8-(4-chlorophenyl)-2-methylpyrazolo[1,5-a]-1,3,5-triazin-4-yl]-3-(ethylamino)-3-azetidinecarboxamide benzenesulfonate salt
• Empirical Formula (Hill Notation): C₂₄H₂₃Cl₂N₇O · C₆H₆O₃S
• CAS Number: 956246-95-0
• Molecular Weight: 654.57
• MDL number: MFCD22666387
• UNSPSC Code: 51111800
• PubChem Substance ID: 329823773
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL (clear solution)
• storage temp.: room temp
• SMILES string: OS(=O)(=O)c1ccccc1.CCNC2(CN(C2)c3nc(C)nc4c(-c5ccc(Cl)cc5)c(nn34)-c6ccccc6Cl)C(N)=O
• InChI: 1S/C24H23Cl2N7O.C6H6O3S/c1-3-28-24(22(27)34)12-32(13-24)23-30-14(2)29-21-19(15-8-10-16(25)11-9-15)20(31-33(21)23)17-6-4-5-7-18(17)26;7-10(8,9)6-4-2-1-3-5-6/h4-11,28H,3,12-13H2,1-2H3,(H2,27,34);1-5H,(H,7,8,9)
• InChI key: PUVYOZFJBITEFT-UHFFFAOYSA-N

Description

Biochem/physiol Actions

CE-178253 is an extremely potent and selective CB1 antagonist with sub-nanomolar potency. In binding assays, CE-178253 has a 0.33 nM Ki for human CB1, vs. a Ki of > 10 mM for human CB2.

Features and Benefits

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301
• Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable