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P0880

Sigma-Aldrich

Pro-Gly

Synonym(s):

L-prolyl-glycine

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About This Item

Empirical Formula (Hill Notation):
C7H12N2O3
CAS Number:
2578-57-6
Molecular Weight:
172.18
MDL number:
MFCD00022391
UNSPSC Code:
12352200
PubChem Substance ID:
24898135
NACRES:
NA.26

Assay

≥98% (TLC)

Quality Level

200

form

powder

technique(s)

cell culture | mammalian: suitable

color

white

application(s)

cell analysis

storage temp.

−20°C

SMILES string

OC(=O)CNC(=O)[C@@H]1CCCN1

InChI

1S/C7H12N2O3/c10-6(11)4-9-7(12)5-2-1-3-8-5/h5,8H,1-4H2,(H,9,12)(H,10,11)/t5-/m0/s1

InChI key

RNKSNIBMTUYWSH-YFKPBYRVSA-N

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Related Categories

Biochem/physiol Actions

PRO-GLY is a dipeptide that has previously been shown to prevent progression of diabetes.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Daisuke Motooka et al.
Biopolymers, 98(2), 111-121 (2011-10-25)
Extensive studies on the structure of collagen have revealed that the hydroxylation of Pro residues in a variety of model peptides with the typical (X-Y-Gly)(n) repeats (X and Y: Pro and its analogues) represents one of the major factors influencing
[Effects of dipeptides Gly-Pro, Pro-Gly, glycine, and proline on the cardiotropic effect of acetylcholine].
N E Babskaia et al.
Biulleten' eksperimental'noi biologii i meditsiny, 126(8), 139-141 (1998-10-20)
Yasutaka Shigemura et al.
Journal of agricultural and food chemistry, 60(20), 5128-5133 (2012-05-03)
Elastin hydrolysate has apparent beneficial effects, and the food-derived peptide prolyl-glycine (Pro-Gly) is present in human blood after oral ingestion. Following ingestion of elastin hydrolysate (10 g/60 kg body weight) by healthy human volunteers, peripheral blood was used to prepare
T A Gudasheva et al.
European journal of drug metabolism and pharmacokinetics, 22(3), 245-252 (1997-07-01)
The metabolism of a new piracetam analogue, the dipeptide cognitive enhancer N-phenylacetyl-L-prolylglycine ethyl ester (GVS-111) was studied in vivo. GVS-111 itself was not found in rat brain 1 h after 5 mg/kg i.p. administration up to limit of detection (LOD)
L A Andreeva et al.
Bulletin of experimental biology and medicine, 153(5), 651-654 (2012-11-01)
Intranasal administration of regulatory peptide PRG to rats against the background of persistent hyperglycemia improves blood antiplatelet and anticoagulant-fibrinolytic potential and normalizes blood sugar in comparison with the corresponding parameters in control animals that did not receive the peptide. The
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