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G2761

Sigma-Aldrich

Gly-Pro-7-amido-4-methylcoumarin hydrobromide

dipeptidylpeptidase IV substrate

Synonym(s):

Gly-Pro-AMC

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About This Item

Empirical Formula (Hill Notation):
C17H19N3O4 · HBr
CAS Number:
115035-46-6
Molecular Weight:
410.26
MDL number:
MFCD00152092
UNSPSC Code:
12352204
PubChem Substance ID:
24895103
NACRES:
NA.32

Assay

≥97% (TLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless to light yellow

storage temp.

−20°C

SMILES string

Br.CC1=CC(=O)Oc2cc(NC(=O)[C@@H]3CCCN3C(=O)CN)ccc12

InChI

1S/C17H19N3O4.BrH/c1-10-7-16(22)24-14-8-11(4-5-12(10)14)19-17(23)13-3-2-6-20(13)15(21)9-18;/h4-5,7-8,13H,2-3,6,9,18H2,1H3,(H,19,23);1H/t13-;/m0./s1

InChI key

PASXTQMFJRHMLJ-ZOWNYOTGSA-N

Application

Gly-Pro-7-amido-4-methylcoumarin hydrobromide has been used as a substrate for determining the dipeptidylpeptidase IV (DPPIV) activity of the extract of Allophylus cominia Sw.

Substrates

Substrate for dipeptidylaminopeptidase IV.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Fluorescence assay of x-prolyl dipeptidyl-aminopeptidase activity with a new fluorogenic substrate.
T Kato et al.
Biochemical medicine, 19(3), 351-359 (1978-06-01)
In vitro anti-diabetic activity of flavonoids and pheophytins from Allophylus cominia Sw. on PTP1B, DPPIV, alpha-glucosidase and alpha-amylase enzymes
Semaan DG, et al.
Journal of Ethnopharmacology, 203, 39-46 (2017)
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