D1285
2′,3′-Dideoxyadenosine
≥97% (HPLC)
Synonym(s):
Dideoxyadenosine, ddA
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About This Item
Empirical Formula (Hill Notation):
C10H13N5O2
CAS Number:
Molecular Weight:
235.24
Beilstein:
619924
EC Number:
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
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Quality Level
Assay
≥97% (HPLC)
form
powder
optical activity
[α]/D -28.0±1.0
mp
181-184 °C (lit.)
solubility
water: 100 mg/mL, clear, colorless
storage temp.
2-8°C
SMILES string
Nc1ncnc2n(cnc12)[C@H]3CC[C@@H](CO)O3
InChI
1S/C10H13N5O2/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(3-16)17-7/h4-7,16H,1-3H2,(H2,11,12,13)/t6-,7+/m0/s1
InChI key
WVXRAFOPTSTNLL-NKWVEPMBSA-N
Gene Information
human ... DCK(1633)
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General description
2′,3′-Dideoxyadenosine is a nucleoside analog of deoxyadenosine. On deamination, it is converted to dideoxyinosine. It inhibits adenylyl cyclase and may play a key role in the inhibition of tumor progression. It is a potent inhibitor of reverse transcriptase enzyme of human immunodeficiency virus.
Application
2′,3′-Dideoxyadenosine (ddA), a specific adenylyl cyclase inhibitor, is useful in biological process and pathway studies involving adenylyl cyclase activity and cAMP pool modulation.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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