162242K
MAPTRIX-L-IKVAV
Laminin Mimetic, aqueous solution
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.75
Recommended Products
sterility
Filtered sterilized solution
form
aqueous solution
mol wt
~23.1 kDa
packaging
pkg of 2.5 mg
concentration
0.5 mg/mL protein
technique(s)
cell culture | mammalian: suitable
Binding Specificity
Receptor: αvβ3, α3β1, α6β1
Domain: α1 L1 - A208
Binding Motif: IKVAV
shipped in
ambient
storage temp.
2-8°C
Application
MAPTrix™ Technology provides a true extracellular microenvironment (ECM) by presenting combinatorial peptide motifs. The ECM, defined by biochemical cues and physical cues, is a deciding factor in a wide range of cellular processes including cell adhesion, proliferation, differentiation, and expression of phenotype-specific functions.Currently existing technology offers simple and merely adequate environments that facilitate simple cell processes such as cellular adhesion. The simple presentation of cell adhesion motifs is not optimal for controlling more integrated processes. Crosstalk among signaling pathways act synergistically to enhance cellular responses such as cell adhesion or proliferation. A study showed that a combination of extracellular matrix derived peptides presented on a surface may enhance cell adhesion strength and focal adhesion assembly. The combinatorial presentation of ECM peptides on cell growth surfaces may also promote elevated proliferation rates of primary or stem cells.
Features and Benefits
- Biochemically-defined, animal-free cell culture surfaces designed to enhance cell performance
- MAPTrix™ produces a uniform ECM surface that provides a highly controlled 2D extracellular microenvironment for cell cultures and related applications
- Adhesion properties of the mussel adhesive protein makes the coating reproducible & reliable
Legal Information
MAPTrix is a trademark of Kollodis Biosciences
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Adhesion and migration are integrated cell functions that build, maintain and remodel the multicellular organism. In migrating cells, integrins are the main transmembrane receptors that provide dynamic interactions between extracellular ligands and actin cytoskeleton and signalling machineries. In parallel to
S J Fashena et al.
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Over the past twenty years, intensive research has enabled us to identify components of specific signalling pathways downstream of an array of adhesion and growth-factor receptors. The first Gordon Research Conference on 'Signalling by Adhesion Receptors', which took place in
Articles
Extracellular matrix proteins such as laminin, collagen, and fibronectin can be used as cell attachment substrates in cell culture.
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