916854
2-(Piperidin-4-yl)benzoic acid hydrochloride
95%
Synonym(s):
Semi-flexible linker for PROTAC® development
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About This Item
Empirical Formula (Hill Notation):
C12H16ClNO2
CAS Number:
Molecular Weight:
241.71
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.22
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Quality Level
Assay
95%
form
powder
reaction suitability
reagent type: linker
functional group
carboxylic acid
storage temp.
2-8°C
SMILES string
O=C(C1=C(C2CCNCC2)C=CC=C1)O.Cl
Related Categories
Application
2-(Piperidin-4-yl)benzoic acid hydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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