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Benomyl

PESTANAL®, analytical standard

Synonym(s):

Methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate, Benomyl, NSC 263489

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About This Item

Empirical Formula (Hill Notation):
C14H18N4O3
CAS Number:
17804-35-2
Molecular Weight:
290.32
Beilstein:
825455
EC Number:
241-775-7
MDL number:
MFCD00084636
UNSPSC Code:
41116107
PubChem Substance ID:
329756662
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

PESTANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

>300 °C (lit.)

application(s)

agriculture
cleaning products
cosmetics
environmental
food and beverages
personal care

format

neat

storage temp.

2-8°C

SMILES string

CCCCNC(=O)n1c(NC(=O)OC)nc2ccccc12

InChI

1S/C14H18N4O3/c1-3-4-9-15-13(19)18-11-8-6-5-7-10(11)16-12(18)17-14(20)21-2/h5-8H,3-4,9H2,1-2H3,(H,15,19)(H,16,17,20)

InChI key

RIOXQFHNBCKOKP-UHFFFAOYSA-N

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General description

Benomyl is characterized under the benzimidazole fungicide and is known to suppress fungal growth in a wide variety of plants. Its mode of action involves inhibition of tubulin polymerization.

Application

Benomyl may be used as a reference standard for the determination of benomyl in aqueous media by high-performance liquid chromatographic method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Muta. 1B - Repr. 1B - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH Annex XVII (Restriction List)

CAS No.

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK1897
BCCH1747
BCCG3581
BCCF8965
BCCC8267

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High-performance liquid chromatographic method for simultaneous determination of benomyl and carbendazim in aqueous media.
Chiba M, et al.
Journal of Agricultural and Food Chemistry, 34(1), 108-112 (1986)
Teratogenic effects of benomyl in the Wistar rat and CD-1 mouse, with emphasis on the route of administration.
Kavlock RJ, et al.
Toxicology and Applied Pharmacology, 62(1), 44-54 (1982)
Deleterious effects of benomyl and carbendazim on human placental trophoblast cells.
Zhou J, et al.
Reproductive Toxicology, 51, 64-71 (2015)
Sadri Znaidi et al.
Eukaryotic cell, 8(6), 806-820 (2009-04-28)
Cap1p, a transcription factor of the basic region leucine zipper family, regulates the oxidative stress response (OSR) in Candida albicans. Alteration of its C-terminal cysteine-rich domain (CRD) results in Cap1p nuclear retention and transcriptional activation. To better understand the function
Miriam Böhm et al.
eLife, 10 (2021-07-27)
Kinetochores are multi-subunit protein assemblies that link chromosomes to microtubules of the mitotic and meiotic spindle. It is still poorly understood how efficient, centromere-dependent kinetochore assembly is accomplished from hundreds of individual protein building blocks in a cell cycle-dependent manner.
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