17929

O-Methyl-O′-succinylpolyethylene glycol 5′000

• Synonym(s): Polyethylene glycol, O-(Succinyl)-O′-methylpolyethylene glycol 5′000, Polyethylene glycol 5000 monomethyl ether succinate
• Linear Formula: CH₃O(CH₂CH₂O)_nCOCH₂CH₂COOH
• CAS Number: 31961-02-1
• MDL number: MFCD00284260
• UNSPSC Code: 51171641
• NACRES: NA.26

Properties

• form: powder
• mol wt: M_r ~5100
• mp: 56-60 °C
• Ω-end: carboxylic acid
• α-end: methoxy
• storage temp.: −20°C

Description

Application

Polyethylene glycol 5000 is used in the construction of biomaterials such as biopolymers, micelles and nanostructures.

Soluble polymer for solid phase synthesis of imines and β-lactams; attaching peptides to PEG

Biochem/physiol Actions

O-Methyl-O′-succinylpolyethylene glycol 5′000 is a modified monomethoxypolyethylene glycol (mPEG) wherein the hydroxyl groups are succinylated by succinic anhydride. This succinylated mPEG can then be used to synthesize tolerogenic mPEG conjugates of peptides. Tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves