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Key Documents

MAB3478

Sigma-Aldrich

Anti-1-cys Peroxiredoxin Antibody, clone 8H11

ascites fluid, clone 8H11, Chemicon®

Synonym(s):

aiPLA2, Peroxiredoxin 6, Non-selenium Glutathione Peroxidase

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

ascites fluid

antibody product type

primary antibodies

clone

8H11, monoclonal

species reactivity

human, rat

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

isotype

IgM

NCBI accession no.

NM_004905.2

UniProt accession no.

P30041

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... PRX(57716)

General description

1-Cys-Peroxiredoxin is a cytosolic protein that is involved in the regulation of cellular redox potential. 1-Cys peroxiredoxin is a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities (Chen, 2000). It can reduce hydrogen peroxide, short chain fatty acids, and phospholipid hydroperoxides and is believed to play a role in phospholipid turnover as well as in the protection against oxidative injury.

Specificity

1-Cys-Peroxiredoxin (Prx VI).

Immunogen

Recombinant human 1-Cys peroxiredoxin.

Application

Detect 1-cys Peroxiredoxin using this Anti-1-cys Peroxiredoxin Antibody, clone 8H11 validated for use in WB, IC, IH.
Research Category
Neuroscience
Research Sub Category
Oxidative Stress
Western blot on rat lung lysate (24 kDa) or recombinant human protein.

Immunohistochemistry on 4% paraformaldehyde fixed rat lung tissue.

Immunocytochemistry on rat type II alveolar epithelial cells.

Optimal working dilutions must be determined by the end user.

Physical form

Ascites fluid. Liquid.

Storage and Stability

Maintain at -20°C in undiluted aliquots up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A B Fisher et al.
American journal of physiology. Lung cellular and molecular physiology, 280(4), L748-L754 (2001-03-10)
This study evaluated the role of a lysosomal-type phospholipase A2 (aiPLA(2)) in the degradation of internalized dipalmitoylphosphatidylcholine (DPPC) and in phospholipid synthesis by the rat lung. Uptake and degradation of DPPC were measured in isolated perfused rat lungs over 3
Seunghyi Kook et al.
The Journal of biological chemistry, 291(16), 8414-8427 (2016-02-26)
The Hermansky Pudlak syndromes (HPS) constitute a family of disorders characterized by oculocutaneous albinism and bleeding diathesis, often associated with lethal lung fibrosis. HPS results from mutations in genes of membrane trafficking complexes that facilitate delivery of cargo to lysosome-related

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