ABS528
Anti-S1P lyase Antibody
from rabbit, purified by affinity chromatography
Synonym(s):
S1PL, SPL1, mSPL, Sphingosine-1-phosphate aldolase
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
mouse ... Sgpl1(20397)
General description
S1P lyase is an important enzyme in lipid, steroid, and ceramide metabolism. S1P lyase 1 specifically cleaves phosphorylated sphingoid bases such as sphingosine-1-phosphate into fatty aldehydes and phosphoethanolamine. S1P lyase also plays roles in apoptosis with regards to regulation of ceramide production and plays roles in cell differentiation via its role in androgen and estrogen metabolism as well as that of other important lipids and bioactive lipid derivatives. S1P lyase is expressed in the endoplasmic reticulum in many cells. Interestingly, because Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that promotes cardiomyocyte survival and contributes to ischemic preconditioning, its catabolism by S1P lyase is very important in recovery from heart attacks or other ischemia related events, and thus S1P lyase is being examined as a potential new therapeutic target for reperfusion therapy in heart disease.
Immunogen
Epitope: cytoplasmic domain
Linear peptide corresponding to the cytoplasmic domain of Mouse S1P lyase.
Application
Research Category
Signaling
Metabolism
Signaling
Metabolism
Research Sub Category
Lipid Metabolism & Weight Regulation
Lipid Signaling
Lipid Metabolism & Weight Regulation
Lipid Signaling
This Anti-S1P lyase Antibody is validated for use in Western Blotting for the detection of S1P lyase.
Western Blotting Analysis: A representative lot of this antibody detected S1P lyase in 30 μg of lysate from various mice tissues (Bektas, M., et al. (2010). Journal of Biological Chemistry Vol. 285, NO. 14, pp. 10880–10889)
Quality
Evaluated by Western Blotting in mouse lung tissue lysate.
Western Blotting Analysis: 1 μg/mL of this antibody detected SP-lyase1 in 10 µg of mouse lung tissue lysate.
Western Blotting Analysis: 1 μg/mL of this antibody detected SP-lyase1 in 10 µg of mouse lung tissue lysate.
Target description
~ 56 kDa observed
Physical form
Antigen Affinity Purified
Purified rabbit polyclonal in buffer with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Certificates of Analysis (COA)
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Younghun Jung et al.
Brain research, 1799, 148171-148171 (2022-11-22)
Sphingolipid-1-phosphate (S1P) signaling through the activation S1P receptors (S1PRs) plays critical roles in cellular events in the brain. Aberrant S1P metabolism has been identified in the brains of Alzheimer's disease (AD) patients. Our recent studies have shown that treatment with
Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver.
Bektas, M; Allende, ML; Lee, BG; Chen, W; Amar, MJ; Remaley, AT; Saba, JD; Proia, RL
The Journal of Biological Chemistry null
Yuko Kageyama et al.
Bioscience reports, 40(7) (2020-07-03)
Liver regeneration is an extremely complicated process that is regulated by a number of signaling pathways. Sphingosine 1-phosphate (S1P), a potent bioactive lipid mediator playing crucial roles in various cellular responses through its receptors, has been attracting attention in the
Baasanjav Uranbileg et al.
Clinical and translational medicine, 12(9), e1056-e1056 (2022-09-21)
In addition to potent agonist properties for sphingosine 1-phosphate (S1P) receptors, intracellularly, S1P is an intermediate in metabolic conversion pathway from sphingolipids to glycerolysophospholipids (glyceroLPLs). We hypothesized that this S1P metabolism and its products might possess some novel roles in
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