AB16942
Anti-DR5 Antibody, CT
Chemicon®, from rabbit
Synonym(s):
Anti-CD262, Anti-DR5, Anti-KILLER, Anti-KILLER/DR5, Anti-TRAIL-R2, Anti-TRAILR2, Anti-TRICK2, Anti-TRICK2A, Anti-TRICK2B, Anti-TRICKB, Anti-ZTNFR9
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All Photos(3)
About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
mol wt
calculated mol wt-47.88 kDa
observed mol wt ~55 kDa
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... TNFRSF10B(8795)
Specificity
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2 or KILLER by several groups independently (Pan et al. 1997; Sheridan et al. 1997; Walczak et al. 1997; MacFarlane et al. 1997; Screaton et al. 1997; Wu et al. 1997; Chaudhary et al. 1997). Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.
Immunogen
Epitope: C-terminus
Polyclonal antibody raised against a peptide corresponding to amino acids 388-407 of human DR5 precursor (Pan et al. 1997; Sheridan et al. 1997).
Application
Anti-DR5 Antibody, C-terminus detects level of DR5 & has been published & validated for use in WB.
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Apoptosis - Additional
Western blot: 1:250 to 1:500
Whole cell lysate from HeLa or K562 cells can be used as a positive control .
Optimal working dilutions must be determined by end user.
Whole cell lysate from HeLa or K562 cells can be used as a positive control .
Optimal working dilutions must be determined by end user.
Physical form
Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.
Format: Purified
Storage and Stability
Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
Other Notes
Click here for more information on observed vs. calculated molecular weight.
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Description
Pricing
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Beneficial effect of glatiramer acetate (Copaxone) on immune modulation of experimental hepatic fibrosis.
Horani, A; Muhanna, N; Pappo, O; Melhem, A; Alvarez, CE; Doron, S; Wehbi, W; Dimitrios et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology null
TRAIL-related death receptors in normal, Lurcher and weaver mutant mouse brain.
Jorg Baurle, Sabine Frischmuth, Karel Kranda
Neuroscience Letters null
P M Chaudhary et al.
Immunity, 7(6), 821-830 (1998-01-16)
Death receptor 4 (DR4) is a recently described receptor for the cytotoxic ligand TRAIL that reportedly uses a FADD-independent pathway to induce apoptosis and does not activate the NF-kappaB pathway. We have isolated a new member of the tumor necrosis
Orhan Aktas et al.
Neuron, 46(3), 421-432 (2005-05-11)
Here, we provide evidence for a detrimental role of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in neural death in T cell-induced experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Clinical severity and neuronal apoptosis in brainstem motor
KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene.
G S Wu et al.
Nature genetics, 17(2), 141-143 (1997-11-05)
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