582243
Tetanus Toxin, Clostridium tetani
Tetanus toxin is produced by Clostridium tetani. Composed of a 100 kDa heavy and a 50 kDa light chain joined by a single interchain disulfide bond.
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
form
lyophilized
manufacturer/tradename
Calbiochem®
availability
not available in Canada,
storage condition
OK to freeze
storage temp.
2-8°C
General description
Produced by the anaerobic bacillus Clostridium tetani. Tetanus toxin is one of the deadliest toxins known. Composed of two polypeptide chains joined by a single interchain disulfide bond. The heavy chain (100 kDa) participates in binding to the nerve terminals, internalization, retrograde axonal transport, and membrane translocation of the light chain (50 kDa) into the neuronal cytosol. The light chain inhibits neurotransmitter release after reduction of the disulfide bridge.
Produced by the anaerobic bacillus Clostridium tetani, Tetanus toxin is one of the deadliest toxins known. Composed of two polypeptide chains joined by a single interchain disulfide bond. The heavy chain (~100 kDa) participates in binding to the nerve terminals, internalization, retrograde axonal transport, and membrane translocation of the light chain (~50 kDa) into the neuronal cytosol. The light chain inhibits neurotransmitter release after reduction of the disulfide bridge.
Tetanus toxin is produced by Clostridium tetani. Composed of a 100 kDa heavy and a 50 kDa light chain joined by a single interchain disulfide bond.
Biochem/physiol Actions
Binds GT1b ganglioside in a hemagglutination assay
Primary Target
Tetanus toxin is one of the deadliest toxins known
Tetanus toxin is one of the deadliest toxins known
Product does not compete with ATP.
Warning
Toxicity: Highly Toxic (H)
Reconstitution
Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.
Please refer to the vial label for lot-specific reconstitution volume.
Analysis Note
Single band by SDS-PAGE
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Montecucco, C., et al. 1994. FEBS Lett. 346, 92.
Wellhöner, H.H., et al. 1987. J. Biol. Chem. 262, 17374.
Wellhöner, H.H., et al. 1987. J. Biol. Chem. 262, 17374.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 1 Oral - Acute Tox. 2 Inhalation - STOT SE 1
Target Organs
Central nervous system
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Certificates of Analysis (COA)
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