1.02066

Calcium carbonate

precipitated for analysis EMSURE^® Reag. Ph Eur

• Linear Formula: CaCO₃
• CAS Number: 471-34-1
• Molecular Weight: 100.09
• Beilstein: 8008338
• MDL number: MFCD00010906
• UNSPSC Code: 12352302
• EC Index Number: 207-439-9

Properties

• Agency: reag. Ph. Eur.
• Quality Level: 300
• product line: EMSURE^®
• Assay: 98.5-100.5% dry basis (complexometric)
• form: solid
• potency: 6450 mg/kg LD₅₀, oral (Rat); >2000 mg/kg LD₅₀, skin (Rat)
• impurities: ≤0.005% Substances insoluble in hydrochloric acid; ≤0.2% Substances insoluble in acetic acid
• loss: ≤ 1.0% loss on drying, 200 °C
• particle size: ~14 μm (D 50)
• pH: 9.5-10.5 (20 °C, 100 g/L in H₂O, slurry)
• mp: 825 °C (decomposition)
• density: 2.93 g/mL at 25 °C (lit.)
• bulk density: 300‑1400 kg/m³
• anion traces: chloride (Cl^-): ≤0.005%; sulfate (SO₄^2-): ≤0.03%
• cation traces: Al: ≤0.005%; As: ≤0.0004%; Ba:, passes test; Cu: ≤0.0005%; Fe: ≤0.001%; K: ≤0.005%; Mg: ≤0.02%; Mg and allied cations: ≤1.5%; N: ≤0.001%; Na: ≤0.2%; Pb: ≤0.0005%; Sr: ≤0.1%; heavy metals (as Pb): ≤0.002%
• storage temp.: 10-30°C
• SMILES string: [Ca++].[O-]C([O-])=O
• InChI: 1S/CH2O3.Ca/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2
• InChI key: VTYYLEPIZMXCLO-UHFFFAOYSA-L

Description

Application

• Comparison of passive targeted delivery of inorganic and organic nanocarriers among different types of tumors.: This study compares the efficiency of calcium carbonate-based nanocarriers in targeted drug delivery across various tumor types, offering insights into their potential for enhancing cancer treatment efficacy (Postovalova et al., 2024).

Analysis Note

Assay (complexometric; calculated on dried substance): 98.5 - 100.5 %
Identity: passes test
Substances insoluble in acetic acid: ≤ 0.2 %
Substances insoluble in hydrochloric acid: ≤ 0.005 %
Chloride (Cl): ≤ 0.005 %
Sulfate (SO₄): ≤ 0.03 %
Heavy metals (as Pb): ≤ 0.002 %
Total nitrogen (N): ≤ 0.001 %
Al (Aluminium): ≤ 0.005 %
As (Arsenic): ≤ 0.0004 %
Ba (Barium): passes test
Cu (Copper): ≤ 0.0005 %
Fe (Iron): ≤ 0.001 %
K (Potassium): ≤ 0.005 %
Mg (Magnesium): ≤ 0.02 %
Na (Sodium): ≤ 0.2 %
Pb (Lead): ≤ 0.0005 %
Sr (Strontium): ≤ 0.1 %
Magnesium and alkali metals: ≤ 1.5 %
Particle size (d 50): about 14 µm
Loss on drying (200 °C): ≤ 1.0 %
Corresponds to Reag. Ph Eur

Legal Information

EMSURE is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable