D125407

DIC

99%

• Synonym(s): N,N′-Diisopropylcarbodiimide
• Linear Formula: (CH₃)₂CHN=C=NCH(CH₃)₂
• CAS Number: 693-13-0
• Molecular Weight: 126.20
• Beilstein: 878281
• EC Number: 211-743-7
• MDL number: MFCD00065689
• UNSPSC Code: 12352111
• PubChem Substance ID: 57654069
• NACRES: NA.22

Properties

• Quality Level: 200
• Assay: 99%
• form: liquid
• reaction suitability: reaction type: Coupling Reactions
• refractive index: n20/D 1.433 (lit.)
• bp: 145-148 °C (lit.)
• density: 0.815 g/mL at 20 °C (lit.)
• application(s): peptide synthesis
• SMILES string: CC(C)N=C=NC(C)C
• InChI: 1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3
• InChI key: BDNKZNFMNDZQMI-UHFFFAOYSA-N
• Gene Information: human ... EPHX2(2053) ; mouse ... Ephx2(13850)

Description

General description

DIC is an abbreviated form of N,N′-diisopropylcarbodiimide. It plays a role in the cyclization of N-(β-hydroxy)amides to form 2-oxazolines.

Application

Coupling reagent for peptide syntheses.

DIC (N,N′-Diisopropylcarbodiimide) has been used in combination with 1-hydroxy-7-azabenzotriazole (HOAt) for the coupling of amino acid with N-allylglycine to form N-allylpeptide.

Alternative to dicyclohexylcarbodiimide in peptide synthesis.

Safety Information

• Pictograms: GHS02,GHS05,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H226 - H317 - H318 - H330 - H334
• Precautionary Statements: P210 - P233 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 1 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Resp. Sens. 1 - Skin Sens. 1
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 91.4 °F
• Flash Point(C): 33 °C
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves