1458009
USP
Neomycin sulfate
United States Pharmacopeia (USP) Reference Standard
Synonym(s):
Neomycin trisulfate salt, Neomycin B sulfate
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About This Item
Empirical Formula (Hill Notation):
C23H46N6O13 · 3H2SO4
CAS Number:
Molecular Weight:
908.88
UNSPSC Code:
41116107
NACRES:
NA.24
grade
pharmaceutical primary standard
API family
neomycin
manufacturer/tradename
USP
application(s)
pharmaceutical (small molecule)
format
neat
InChI
1S/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22?,23+;/m1./s1
InChI key
OIXVKQDWLFHVGR-GQTDVWSESA-N
General description
Neomycin Sulfate is the sulfate salt of a kind of neomycin, an antibacterial substance produced by the growth of Streptomyces fradiae Waksman (Fam. Streptomycetaceae), or a mixture of two or more such salts, the main component being neomycin B sulfate. It has a potency equivalent to NLT 600 µg of neomycin/mg, calculated on the dried basis.
Neomycin sulfate USP reference standard is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets, has been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Neomycin sulfate USP reference standard is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets, has been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Neomycin sulfate USP reference standard intended for use in specified quality tests and assays. It is also used to prepare sample solution for assay of Polymyxin B according to the given below monographs of United States Pharmacopeia (USP):
- Neomycin and Polymyxin B Sulfates and Hydrocortisone Ophthalmic Suspension
- Neomycin and Polymyxin B Sulfates Ophthalmic Ointment
- Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Lidocaine Ointment
- Neomycin and Polymyxin B Sulfates and Lidocaine Cream
- Neomycin Sulfate and Hydrocortisone Otic Suspension
- Neomycin and Polymyxin B Sulfates and Hydrocortisone Otic Suspension
Further information is available in the monograph, Neomycin Sulfate, USP43-NF38 - 3120, USP43-NF38 - 3126, etc of the USP (United States Pharmacopeia).
Caution
Stock solutions should be filter sterilized and stored at 2-8°C, and are stable at 37°C for 5 days. A 1 mg/mL neomycin solution in .1 M phosphate buffer, pH 8.0 should be used within 14 days when stored at 0-5°C. Solutions should be protected from light or moisture.
Preparation Note
Neomycin sulfate is soluble in H2O at 50 mg/mL, yielding a clear solution.
Other Notes
This product is part of the USP Biologics program.
Legal Information
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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