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Key Documents

WH0003558M3

Sigma-Aldrich

Monoclonal Anti-IL2 antibody produced in mouse

clone 3C8, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-IL2, Anti-TCGF, Anti-interleukin 2, Anti-lymphokine

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About This Item

MDL number:
MFCD00675261
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

3C8, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable

isotype

IgG2aκ

GenBank accession no.

N/A

UniProt accession no.

P60568

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IL2(3558)

General description

Interleukin 2 (IL2) is synthesised by immunoregulatory T helper cells. IL2 consists of three subunits, in which the beta subunit is critical for receptor mediated signalling. IL2 gene is located on human chromosome 4q27.

Immunogen

IL2 (NP_000577, 21 a.a. ~ 153 a.a) recombinant protein.

Sequence
MAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFSQSIISTLT

Biochem/physiol Actions

Interleukin 2 (IL2) promotes the development of suppressor T regulatory cells. IL2 plays a crucial role in antitumor immunity. IL2 destabilises adherens junctions, and cytoskeletal reorganization, causing increased endothelial cell permeability.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Polymorphisms and haplotypes of the interleukin 2 gene are associated with an increased risk of gastric cancer. The possible involvement of Helicobacter pylori
Melchiade, et al.
Cytokine, 96 (2017)
The main function of IL-2 is to promote the development of T regulatory cells
Malek, Th, et al.
Journal of Leukocyte Biology, 74(6) (2003)
Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases
Zhernakova A, et al.
American Journal of Human Genetics, 81(6), 1284-1288 (2007)
The IL-2 receptor complex: its structure, function, and target genes
Minami, Y, et al.
Annual Review of Immunology, 11(1) (1993)
Linyi Zhang et al.
Cell & bioscience, 4, 51-51 (2014-01-01)
Naturally occurring regulatory T cells (Tregs) play a pivotal role in the maintenance of self-tolerance due to their intrinsic immunosuppressive activity. Currently, a number of human clinical trials are being conducted to investigate the roles of Tregs in treating various
View All Related Papers

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