SRP6301
Apolipoprotein A-IV from human plasma
≥85% (SDS-PAGE)
Synonym(s):
Apo-AIV, ApoA-IV, Apolipoprotein A-IV, apo AIV
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
biological source
human plasma
Assay
≥85% (SDS-PAGE)
form
frozen liquid
mol wt
46 kDa
packaging
pkg of 50 μg
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... ApoA4(337)
General description
Apolipoprotein (apo)A-IV4 is a lipid-binding protein. It is produced by the small intestine and liberated into the gastric lymphatics. A-IV4 belongs to the exchangeable apolipoproteins family. This gene is located on human chromosome 11q23.
Apolipoprotein AIV (Apo AIV) is a glycoprotein synthesized by the human intestine. Synthesis appears to be stimulated by the absorption of high density lipoproteins that are rich in triglycerides rather than by the uptake or re-esterification of fatty acids. The formation of chylomicrons acts as a signal for the induction of Apo AIV synthesis a signal enhanced by a factor from the ileum, probably PYY. Apo AIV alters the activity of the key enzymes (LPL and LCAT) of lipoprotein metabolism and cholesterol efflux from extra hepatic tissues. Also, since stimulation of intestinal synthesis and secretion by lipid absorption are rapid, Apo AIV likely plays a role in the short-term regulation of food intake. Other evidence suggests involvement in the long-term regulation of both food intake and body weight. Chronic ingestion of high-fat diet blunts the intestinal Apo AIV response to lipid feeding and, consequently, may explain why the chronic ingestion of a high-fat diet predisposes both animals and humans to obesity. It is required for efficient activation of lipoprotein lipase by ApoC-II and is a potent activator of LCAT. Apo AIV is an amphipathic protein that can emulsify lipids and has been linked to protective roles against cardiovascular disease and obesity.
Biochem/physiol Actions
Apolipoprotein (apo)A-IV participates in dietary lipid and glucose metabolism. It inhibits oxidation of lipids and represses inflammation. A-IV plays a major role in changing the glucose sensitivity of pancreatic islets to alter insulin secretion.
Physical form
Frozen in 10 mM NH4HCO3, pH 8.2.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Role of conserved proline residues in human apolipoprotein A-IV structure and function.
Deng X, et al.
The Journal of Biological Chemistry, 290(17), 10689?10702-10689?10702 (2015)
Effects of interacting networks of cardiovascular risk genes on the risk of type 2 diabetes mellitus (the CODAM study).
van Greevenbroek MM, et al.
BMC Medical Genetics, 9(1), 36-36 (2008)
The Structure of Human Apolipoprotein A-IV as Revealed by Stable Isotope Assisted Cross-linking, Molecular Dynamics and Small Angle X-ray Scattering.
Walker RG, et al.
The Journal of Biological Chemistry, 289(9), 5596?5608-5596?5608 (2014)
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