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R2530

Sigma-Aldrich

Ropinirole hydrochloride

powder, ≥98% (HPLC)

Synonym(s):

4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride, SKF 101468 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H24N2O · HCl
CAS Number:
91374-20-8
Molecular Weight:
296.84
MDL number:
MFCD01754173
UNSPSC Code:
12352200
PubChem Substance ID:
329824018
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

light yellow

solubility

H2O: >10 mg/mL

originator

GlaxoSmithKline

SMILES string

Cl.CCCN(CCC)CCc1cccc2NC(=O)Cc12

InChI

1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H

InChI key

XDXHAEQXIBQUEZ-UHFFFAOYSA-N

Gene Information

human ... DRD2(1813) , DRD3(1814) , DRD4(1815)

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Biochem/physiol Actions

An agonist at the D2 and D3 dopamine receptor subtypes, binding with higher affinity to D3 than to D2 or D4. It has negligible effect on D1-receptors. It has medium in vitro affinity to opioid receptors. Ropinirole is said to have virtually no affinity to 5-HT1, 5-HT2, benzodiazepine, GABA, muscarinic, α1-, α2-, and β-adrenoreceptors. Used as antiparkinsonian drug.
Ropinirole hydrochloride is effectively used to treat early and late Parkinson′s disease.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H302,H400

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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T Nissen et al.
Scottish medical journal, 57(4), 217-220 (2012-09-25)
The expected duration of initial antiparkinson monotherapy before the need for supplementation is not clearly defined for routine practice. The aim of this study was to define the length of L-dopa (L-3, 4-dihydrophenylalanine) and dopamine agonist monotherapy. The duration of
Naoto Kohno et al.
Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology, 25(2), 98-102 (2012-05-19)
We describe a 76-year-old man with herpes encephalitis whose symptom of severe apathy was improved by the dopamine D2/D3 receptor agonist ropinirole. Brain magnetic resonance imaging had shown lesions in the patient's right mesial temporal cortex, right insula, and bilateral
Dopamine agonist withdrawal syndrome in a patient with restless legs syndrome.
Benjamin J Dorfman et al.
Parkinsonism & related disorders, 19(2), 269-270 (2012-07-04)
N Hattori et al.
Journal of clinical pharmacy and therapeutics, 37(5), 571-577 (2012-03-07)
Ropinirole hydrochloride, a dopamine receptor agonist with a non-ergot alkaloid structure, is highly selective for the dopamine D(2) /D(3) receptors. This study was conducted to evaluate the steady-state pharmacokinetics, safety and efficacy after repeated oral administration of prolonged-release tablets of
Francisco J Zagmutt et al.
The International journal of neuroscience, 122(7), 345-353 (2012-02-07)
The comparative safety profiles of monotherapeutic treatments for Parkinson's disease (PD) can provide valuable therapeutic information. The objective of this study was to perform an indirect comparison of Adverse Events (AEs) and Dropout Rates (DRs) among clinical trials of pramipexole
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