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P3886

Sigma-Aldrich

Poly-L-proline

suitable for ligand binding assays, Mol wt >30,000

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About This Item

Empirical Formula (Hill Notation):
C5H9NO2
CAS Number:
25191-13-3
Molecular Weight:
115.13
MDL number:
MFCD00166364
UNSPSC Code:
12352209
PubChem Substance ID:
24898465
NACRES:
NA.26

product name

Poly-L-proline, mol wt >30,000

form

powder

mol wt

>30,000

technique(s)

ligand binding assay: suitable

color

white to light yellow

storage temp.

−20°C

SMILES string

OC(=O)C1CCCN1

InChI

1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)

InChI key

ONIBWKKTOPOVIA-UHFFFAOYSA-N

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Analysis Note

Molecular weight based on viscosity.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Christopher J Woolstenhulme et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(10), E878-E887 (2013-02-23)
Although the ribosome is a very general catalyst, it cannot synthesize all protein sequences equally well. For example, ribosomes stall on the secretion monitor (SecM) leader peptide to regulate expression of a downstream gene. Using a genetic selection in Escherichia
Michael A Purdy
Journal of virology, 86(18), 10186-10193 (2012-07-20)
The hepatitis E virus (HEV) polyproline region (PPR) is an intrinsically unstructured region (IDR). This relaxed structure allows IDRs, which are implicated in the regulation of transcription and translation, to bind multiple ligands. Originally the nucleotide variability seen in the
W Austin Elam et al.
Biochemistry, 52(5), 949-958 (2013-01-29)
The native states of globular proteins have been accessed in atomic detail by X-ray crystallography and nuclear magnetic resonance spectroscopy, yet characterization of denatured proteins beyond global metrics has proven to be elusive. Denatured proteins have been observed to exhibit
M Ashtari et al.
Journal of chromatography. A, 1265, 70-87 (2012-10-17)
Poly-proline chains and derivatives have been recently examined as the basis for new chiral stationary phases in high performance liquid chromatography. The selectivity of poly-proline has been measured for peptides with up to ten proline units. In this article, we
Biochemistry. Getting past polyproline pauses.
Allen R Buskirk et al.
Science (New York, N.Y.), 339(6115), 38-39 (2013-01-05)
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Articles

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

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