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M3949

Sigma-Aldrich

MST-312

≥98% (HPLC)

Synonym(s):

N,N′-1,3-Phenylenebis-[2,3-dihydroxy-benzamide]

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About This Item

Empirical Formula (Hill Notation):
C20H16N2O6
CAS Number:
368449-04-1
Molecular Weight:
380.35
MDL number:
MFCD24368986
UNSPSC Code:
12352200
PubChem Substance ID:
329817985
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

off-white to light tan

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

SMILES string

Oc1cccc(C(=O)Nc2cccc(NC(=O)c3cccc(O)c3O)c2)c1O

InChI

1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28)

InChI key

MIQUEZGHEJGPJB-UHFFFAOYSA-N

Application

MST-312 has been used in cell invasion assay using mouse fibroblast cells (NIH-3T3) and in the co-immunoprecipitation experiments in colon fibroblast.

Biochem/physiol Actions

MST-312 is a telomerase Inhibitor. Telomeres are nucleoprotein complexes present on the ends of chromosomes, containing DNA segment tandem repeats that shorten with each repetitive cell cycle. Telomere shortening leads to loss of function, resulting in cell senescence and limited survivability. The reverse transcriptase, telomerase, maintains telomere length and function in immortalized cell lines and most cancer cell lines, and telomerase activity is associated with tumorigenesis. Telomere elongation is also believed to be an important contributor to the genomic stability and indefinite self renewal of iPS cells. 1 μM MST-312 was shown to effectively reduce telomere length and inhibit proliferation in U937 cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Salinomycin abolished STAT3 and STAT1 interactions and reduced telomerase activity in colorectal cancer cells.
Chung SS, et al.
Anticancer Research, 37(2), 445-453 (2017)
Laurent Lacroix et al.
Nucleic acids research, 39(4), e21-e21 (2010-11-26)
RNA and DNA guanine-rich sequences can adopt unusual structures called Guanine quadruplexes (G4). A quadruplex-prone RNA sequence is present at the 5'-end of the 451-nt-long RNA component of telomerase, hTERC. As this quadruplex may interfere with P1 helix formation, a
Combination treatment with flavonoid morin and telomerase inhibitor MST-312 reduces cancer stem cell traits by targeting STAT3 and telomerase.
Chung SS, et al.
International Journal of Oncology, 49(2), 487-498 (2016)
Yancong Kong et al.
The Analyst, 144(15), 4694-4701 (2019-07-04)
The development of facile and sensitive miRNA quantitative detection methods is a central challenge for the early diagnosis of miRNA-related diseases. Herein, we propose a strategy for a liposome-encoded magnetic bead-based DNA toehold-mediated DNA circuit for the simple and sensitive
Stina George Fernandes et al.
Translational oncology, 27, 101569-101569 (2022-10-25)
Quercetin is a natural flavonoid with well-established anti-proliferative activities against a variety of cancers. Telomerase inhibitor MST-312 also exhibits anti-proliferative effect on various cancer cells independent of its effect on telomere shortening. However, due to their low absorption and toxicity
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