I9534

Monoclonal Anti-Insulin-like Growth Factor-II antibody produced in rat

clone 122404, purified immunoglobulin, lyophilized powder

• Synonym(s): Anti-Igf-II, Anti-Igf2, Anti-Mpr, Anti-Peg2
• UNSPSC Code: 51111800
• NACRES: NA.41

Properties

• biological source: rat
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 122404, monoclonal
• form: lyophilized powder
• species reactivity: mouse
• technique(s): capture ELISA: 2-8 μg/mL; western blot: 1-2 μg/mL
• isotype: IgG2a
• UniProt accession no.: P09535
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: mouse ... Igf2(16002)

Description

Immunogen

purified, E. coli-derived recombinant mouse insulin-like growth factor-II.

Biochem/physiol Actions

Insulin-like growth factors -I and -II are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -II (IGF-II) is widely expressed during embryonic stages and regulates the placental development. IGF-II acts via specific receptor, IGF-IIR, the binding does not result in signal transduction, but is a mechanism to restrict the bioavailability of IGF-II. The effects of IGF-II signaling are important in growth of blood vessels (angiogenesis) gene transcription, proliferation and transformation.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves