D2571

DPPE hydrochloride

≥98% (HPLC)

• Synonym(s): BMS-217380-01, N,N-Diethyl-2-[4-(phenylmethyl) phenoxy]ethanamine hydrochloride, Tesmilifene hydrochloride, YMB1002, [2-(4-Benzyl-phenoxy)-ethyl]-diethyl-amine hydrochloride
• Empirical Formula (Hill Notation): C₁₉H₂₅NO·HCl
• CAS Number: 92981-78-7
• Molecular Weight: 319.87
• MDL number: MFCD11114012
• UNSPSC Code: 51111800
• PubChem Substance ID: 329798745
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white
• solubility: H₂O: 16 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.CCN(CC)CCOc1ccc(Cc2ccccc2)cc1
• InChI: 1S/C19H25NO.ClH/c1-3-20(4-2)14-15-21-19-12-10-18(11-13-19)16-17-8-6-5-7-9-17;/h5-13H,3-4,14-16H2,1-2H3;1H
• InChI key: TXLHNFOLHRXMAU-UHFFFAOYSA-N

Description

Biochem/physiol Actions

DPPE is a potent, selective ligand of the microsomal anti-estrogen binding site.

DPPE is a potent, selective ligand of the microsomal anti-estrogen binding site. DPPE is a tamoxifen derivataive that binds with high affinity to the anti-estrogen binding site, but unlike tamoxifen, does not bind to the estrogen receptor. DPPE sensitizes MDR tumor cells to chemotherapy and also inhibits histamine binding at the intracellular histamine site.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable