94261
LL-37 (human) trifluoroacetate salt
≥95% (HPLC)
Synonym(s):
Human LL-37 amide Trifluoroacetate
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About This Item
Empirical Formula (Hill Notation):
C205H341N61O52 · xC2HF3O2
Molecular Weight:
4492.28 (free base basis)
UNSPSC Code:
51101500
NACRES:
NA.85
Recommended Products
Assay
≥95% (HPLC)
form
powder (Lyophilisate)
color
colorless to white
solubility
H2O: 1 mg/mL, clear, colorless
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
viruses
Mode of action
cell membrane | interferes
storage temp.
−20°C
Amino Acid Sequence
Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-NH2
General description
Chemical structure: peptide
Application
LL-37 is used to study host defense mechanisms.
Biochem/physiol Actions
LL-37 is a muntifunctional host defense peptide with antibacterial, antiviral, and immunomodulating activities. It is the only cathelicidin-type peptide found in human. In addition to its antimicrobial activities, LL-37 has been found to regulate inflammation and neutralize lipopolysaccharides from Gram-negative bacteria.
Packaging
1mg
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Keep in a dry place.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Bce-like systems mediate resistance against antimicrobial peptides in Firmicutes bacteria. Lactobacillus casei BL23 encodes an "orphan" ABC transporter that, based on homology to BceAB-like systems, was proposed to contribute to antimicrobial peptide resistance. A mutant lacking the permease subunit was
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