345547

Hydrogen chloride solution

4.0 M in dioxane

• Empirical Formula (Hill Notation): HCl
• CAS Number: 7647-01-0
• Molecular Weight: 36.46
• MDL number: MFCD00011324
• UNSPSC Code: 12352301
• PubChem Substance ID: 329755029
• NACRES: NA.21

Properties

• form: liquid
• Quality Level: 200
• concentration: 3.80-4.40 M (by NaOH, titration); 4.0 M in dioxane
• density: 1.05 g/mL at 25 °C
• SMILES string: Cl
• InChI: 1S/ClH/h1H
• InChI key: VEXZGXHMUGYJMC-UHFFFAOYSA-N

Description

General description

Hydrogen chloride solution contains 4.0 M hydrogen chloride in 1,4-dioxane as the solvent. It is commonly used as a deprotection reagent during the deprotection of the tert-butoxycarbonyl (Boc) group of various amino acids and peptides. Additionally, it serves as a reagent in various organic synthesis reactions, including the synthesis of N-9-Fluorenylmethoxycarbonyl- (Fmoc) amino-acid chlorides.

Application

Hydrogen chloride solution (4.0 M in dioxane) can be used as:     

• A reagent for the deprotection of the N-Boc protecting group from various heterocyclic derivatives.     
• A reagent for the deprotection of polymer protecting groups. For instance, deprotection of benzyl ether-protected polymer.      
• A polymerization initiator in combination with ZnCl₂ in the synthesis of formyl terminated poly(ethyl vinyl ether) from ethyl vinyl ether (EVE).

Safety Information

• Pictograms: GHS02,GHS08,GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H225,H290,H315,H319,H335,H350
• Precautionary Statements: P202 - P210 - P233 - P303 + P361 + P353 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Supplementary Hazards: EUH019
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 62.6 °F - closed cup
• Flash Point(C): 17 °C - closed cup